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Steap3  -  STEAP family member 3

Mus musculus

Synonyms: 1010001D01Rik, Dudulin-2, Metalloreductase STEAP3, Protein nm1054, Six-transmembrane epithelial antigen of prostate 3, ...
 
 
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Disease relevance of Steap3

  • Using a positional cloning strategy, we identified a gene, six-transmembrane epithelial antigen of the prostate 3 (Steap3), responsible for the iron deficiency anemia in the mouse mutant nm1054 [1].
  • A novel gene (pHyde) was identified by an improved cDNA competition hybridization technique for Dunning rat prostate cancer cell lines [2].
  • A recombinant adenovirus containing pHyde cDNA gene (AdpHyde) was generated to investigate the biological function of pHyde protein [3].
 

High impact information on Steap3

  • Steap3 is expressed highly in hematopoietic tissues, colocalizes with the Tf cycle endosome and facilitates Tf-bound iron uptake [1].
  • Overexpression of Steap3 stimulates the reduction of iron, and mice lacking Steap3 are deficient in erythroid ferrireductase activity [1].
  • Previously, we identified a mammalian ferrireductase, Steap3, critical for erythroid iron homeostasis [4].
  • These results together suggest that pHyde is a tumor suppressor gene that inhibits growth of prostate cancer and that this inhibition is at least in part due to the induction of apoptosis [2].
  • Moreover, cancer cells that lacked expression of endogenous caspase-3 were not or barely inhibited by pHyde [3].
 

Biological context of Steap3

  • These results taken together suggest that pHyde inhibits cancer growth by inducing apoptosis through a caspase-3 dependent pathway [3].
 

Other interactions of Steap3

 

Analytical, diagnostic and therapeutic context of Steap3

  • Based on the results presented herein, PAP-3 and STEAP-3 are naturally processed CTL epitopes possessing anti-prostate cancer reactivity in vivo and therefore may constitute vaccine candidates to be investigated in clinical trials [5].

References

  1. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Ohgami, R.S., Campagna, D.R., Greer, E.L., Antiochos, B., McDonald, A., Chen, J., Sharp, J.J., Fujiwara, Y., Barker, J.E., Fleming, M.D. Nat. Genet. (2005) [Pubmed]
  2. Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde. Steiner, M.S., Zhang, X., Wang, Y., Lu, Y. Cancer Res. (2000) [Pubmed]
  3. Apoptosis induction in prostate cancer cells by a novel gene product, pHyde, involves caspase-3. Zhang, X., Steiner, M.S., Rinaldy, A., Lu, Y. Oncogene (2001) [Pubmed]
  4. The Steap proteins are metalloreductases. Ohgami, R.S., Campagna, D.R., McDonald, A., Fleming, M.D. Blood (2006) [Pubmed]
  5. Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy. Machlenkin, A., Paz, A., Bar Haim, E., Goldberger, O., Finkel, E., Tirosh, B., Volovitz, I., Vadai, E., Lugassy, G., Cytron, S., Lemonnier, F., Tzehoval, E., Eisenbach, L. Cancer Res. (2005) [Pubmed]
 
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