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Gene Review:

H1fnt - H1 histone family, member N, testis-specific

Mus musculus

Synonyms: 1700026P10Rik, H1.7, H1T2, H1t2, Hanp1, ...

Tanaka, H. et al., Martianov, I. et al.

Tanaka, Matsuoka, Onishi, Kitamura, Miyagawa, Nishimura, Tsujimura, Okuyama, Nishimune,

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Disease relevance of H1fnt

To investigate the roles of human HANP1 (h-HANP1) and its relation to male infertility, we isolated h-HANP1 cDNA from a human cDNA plasmid library using mouse Hanp1 cDNA as a probe. h-HANP1 is expressed in the testes and its genomic construct also intronless as mouse Hanp1 [1].

High impact information on H1fnt

Analysis of spermiogenesis in H1t2 mutant mice shows delayed nuclear condensation and aberrant elongation [2].

References

Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. Tanaka, H., Matsuoka, Y., Onishi, M., Kitamura, K., Miyagawa, Y., Nishimura, H., Tsujimura, A., Okuyama, A., Nishimune, Y. Int. J. Androl. (2006) [Pubmed]
Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. Martianov, I., Brancorsini, S., Catena, R., Gansmuller, A., Kotaja, N., Parvinen, M., Sassone-Corsi, P., Davidson, I. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

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