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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Capn9  -  calpain 9

Mus musculus

Synonyms: 2200003B16Rik, Calpain-9, Digestive tract-specific calpain, GC36, Ncl4, ...
 
 
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High impact information on Capn9

  • The gene inactivated by RHKO was identified as nCL-4 by genomic library screening, transcript analysis, and DNA sequencing [1].
  • Here we report the discovery that RHKO-mediated deficiency of the nCL-4 calpain protease results in cellular transformation of and tumorigenesis by murine NIH3T3 fibroblasts [1].
  • In the case of human nCL-4, the longest open reading frame encodes 690 amino acid residues (Mr 79095) with equal sequence similarities (50-55%) to both ubiquitous and organ-specific calpain large subunits from mammals [2].
  • When overexpressed in COS-7 cells, a specific band for nCL-4 was detected [2].

References

  1. Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis. Liu, K., Li, L., Cohen, S.N. J. Biol. Chem. (2000) [Pubmed]
  2. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Lee, H.J., Sorimachi, H., Jeong, S.Y., Ishiura, S., Suzuki, K. Biol. Chem. (1998) [Pubmed]
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