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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZNF22  -  zinc finger protein 22

Homo sapiens

Synonyms: HKR-T1, KOX15, KROX26, ZNF422, Zfp422, ...
 
 
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Disease relevance of ZNF22

  • A unique kindred manifesting medullary thyroid carcinoma and corneal nerve thickening without other aspects of the multiple endocrine neoplasia syndrome (MEN) was analyzed by linkage analysis using four highly polymorphic (CA)n repeat markers (sTCL-1, D10S141, ZNF22, and sJRH-1) [1].
  • Ten kindreds (95 individuals) with multiple endocrine neoplasia, type 2 (MEN 2) were analyzed by linkage analysis using four highly polymorphic (CA)n-repeat markers (sTCL-1, D10S141, ZNF22, and sJRH-1) [2].
 

High impact information on ZNF22

  • Furthermore, the amino-terminal region of RelA did not associate with several other transcription factors, including MyoD, E12, or Kox15, another zinc finger protein [3].
  • A polymorphic dinucleotide repeat at the ZNF22 locus [4].
  • The KROX-26 gene was mapped to chromosome 10q11.21, a locus that has been associated with permanent tooth agenesis (He-Zhao deficiency) [5].
  • During fetal development, KROX-26 is expressed in the epithelial component of the developing tooth organ during early bud and cap stages as well as in osteoblasts of craniofacial bone and the developing tongue [5].

References

  1. Familial medullary thyroid cancer and prominent corneal nerves: clinical and genetic analysis. Kane, L.A., Tsai, M.S., Gharib, H., Khosla, S., Robertson, D.M., Schaid, D.J., Honchel, R., Thibodeau, S.N. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  2. Identification of multiple endocrine neoplasia, type 2 gene carriers using linkage analysis and analysis of the RET proto-oncogene. Tsai, M.S., Ledger, G.A., Khosla, S., Gharib, H., Thibodeau, S.N. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  3. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Perkins, N.D., Agranoff, A.B., Pascal, E., Nabel, G.J. Mol. Cell. Biol. (1994) [Pubmed]
  4. A polymorphic dinucleotide repeat at the ZNF22 locus. Love, D.R., Gardner, E., Ponder, B.A. Hum. Mol. Genet. (1993) [Pubmed]
  5. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). Gao, Y., Kobayashi, H., Ganss, B. J. Dent. Res. (2003) [Pubmed]
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