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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nt5c2  -  5'-nucleotidase, cytosolic II

Mus musculus

Synonyms: 2010002I23Rik, CnII, Cytosolic 5'-nucleotidase II, Cytosolic purine 5'-nucleotidase, ENSMUSG00000025039, ...
 
 
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High impact information on Nt5c2

  • Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway [1].
  • L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway [2].
  • BACKGROUND: The glutamate-nitric oxide-cyclic GMP pathway has been identified as a potential target for volatile anaesthetic agents as acute inhibition of nitric oxide synthase (NOS) reduces the minimum alveolar concentration (MAC) in most animal studies [3].
  • Our results indicate that the NMDA receptor-nitric oxide-cyclic GMP pathway remains a credible target in modulating the effects of isoflurane [3].
  • Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway [4].
 

Anatomical context of Nt5c2

  • These findings suggest that FR140423 plays a role in nociceptive modulation in the spinal cord, being antinociceptive via the kyotorphin-Met-enkephalin pathway but not via the peripheral NO-cyclic GMP pathway [5].
 

Associations of Nt5c2 with chemical compounds

References

  1. Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway. Tahsili-Fahadan, P., Yahyavi-Firouz-Abadi, N., Orandi, A.H., Esmaeili, B., Basseda, Z., Dehpour, A.R. Psychopharmacology (Berl.) (2006) [Pubmed]
  2. L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway. Kawabata, A., Umeda, N., Takagi, H. Br. J. Pharmacol. (1993) [Pubmed]
  3. Inhibition of neuronal nitric oxide synthase reduces isoflurane MAC and motor activity even in nNOS knockout mice. Engelhardt, T., Lowe, P.R., Galley, H.F., Webster, N.R. British journal of anaesthesia. (2006) [Pubmed]
  4. Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Jain, N.K., Patil, C.S., Singh, A., Kulkarni, S.K. Brain Res. (2001) [Pubmed]
  5. The spinal antinociceptive effect of FR140423 is mediated through kyotorphin receptors. Ochi, T., Motoyama, Y., Goto, T. Life Sci. (2000) [Pubmed]
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