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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GPR63  -  G protein-coupled receptor 63

Homo sapiens

Synonyms: PSP24(beta), PSP24-2, PSP24-beta, PSP24B
 
 
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Disease relevance of GPR63

 

High impact information on GPR63

  • The discovery that S1P, dihydro-S1P and dioleoylphosphatidic acid activate GPR63 will facilitate the identification of agonists and antagonists, and help to unravel the biological function of this receptor [1].
  • All three phospholipids mobilise intracellular calcium in CHO cells transiently transfected with GPR63 [1].
  • A search of the GenBank genomic sequence databases revealed three previously unrecognized intronless genes encoding the orphan GPCrs (oGPCRs) GPR62, GPR63 and GPR77, with respective amino acid lengths of 368, 419 and 337 [2].
  • GPR63 mRNA expression was detected in the frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain [2].
 

Associations of GPR63 with chemical compounds

References

  1. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Niedernberg, A., Tunaru, S., Blaukat, A., Ardati, A., Kostenis, E. Cell. Signal. (2003) [Pubmed]
  2. Identification of four novel human G protein-coupled receptors expressed in the brain. Lee, D.K., George, S.R., Cheng, R., Nguyen, T., Liu, Y., Brown, M., Lynch, K.R., O'Dowd, B.F. Brain Res. Mol. Brain Res. (2001) [Pubmed]
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