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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GDPD5  -  glycerophosphodiester phosphodiesterase...

Homo sapiens

Synonyms: GDE2, Glycerophosphodiester phosphodiesterase 2, Glycerophosphodiester phosphodiesterase domain-containing protein 5, PP1665, PP6037, ...
 
 
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High impact information on GDPD5

  • Immunohistochemical analyses using anti-GDE2 antibody showed that GDE2 protein is expressed in the epithelial cell layer of mouse lung [1].
  • Here, we isolated two cDNAs encoding serpentine membrane proteins, GDE2 and GDE6, containing GP-PDE motif from mouse cDNA libraries [1].
  • Although GDE3 mRNA is highly expressed in bone tissue and spleen, GDE2 mRNA was expressed in a variety of mouse tissues including lung and heart, while the GDE6 transcript was particularly abundant in spermatocytes of mouse testis [1].
  • In amino acid sequences, GDE2 and GDE6 are 43.7% and 34.3% identical to GDE3, respectively [1].
  • Transmembrane protein GDE2 induces motor neuron differentiation in vivo [2].

References

  1. Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6. Nogusa, Y., Fujioka, Y., Komatsu, R., Kato, N., Yanaka, N. Gene (2004) [Pubmed]
  2. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Rao, M., Sockanathan, S. Science (2005) [Pubmed]
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