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Gene Review:

TRIM11 - tripartite motif containing 11

Homo sapiens

Synonyms: BIA1, E3 ubiquitin-protein ligase TRIM11, Protein BIA1, RING finger protein 92, RNF92, ...

Ishikawa, H. et al., Niikura, T. et al.

Niikura, Hashimoto, Tajima, Ishizaka, Yamagishi, Kawasumi, Nawa, Terashita, Aiso, Nishimoto,

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High impact information on TRIM11

In addition, TRIM11 suppressed ARC105-mediated transcriptional activation induced with TGFbeta in a reporter assay [1].
Disruption of the RING finger domain by deleting the first consensus cysteine or proteasome inhibitor treatment significantly diminished the effect of TRIM11 on the intracellular level of HN [2].
The intracellular level of glutathione S-transferase-fused or EGFP-fused HN peptides or plain HN was drastically reduced by the coexpression of TRIM11 [2].

Physical interactions of TRIM11

In this study, we demonstrate that TRIM11 interacts with activator-recruited cofactor 105-kDa component (ARC105) that mediates chromatin-directed transcription activation and is a key regulatory factor for transforming growth factor beta (TGFbeta) signaling [1].

Other interactions of TRIM11

Co-expression of TRIM11 and ARC105 also increased ubiquitination of ARC105 [1].

References

TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. Ishikawa, H., Tachikawa, H., Miura, Y., Takahashi, N. FEBS Lett. (2006) [Pubmed]
A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Niikura, T., Hashimoto, Y., Tajima, H., Ishizaka, M., Yamagishi, Y., Kawasumi, M., Nawa, M., Terashita, K., Aiso, S., Nishimoto, I. Eur. J. Neurosci. (2003) [Pubmed]

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TRIM11	Pan troglodytes

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