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Gene Review

TRIM11  -  tripartite motif containing 11

Homo sapiens

Synonyms: BIA1, E3 ubiquitin-protein ligase TRIM11, Protein BIA1, RING finger protein 92, RNF92, ...
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High impact information on TRIM11

  • In addition, TRIM11 suppressed ARC105-mediated transcriptional activation induced with TGFbeta in a reporter assay [1].
  • Disruption of the RING finger domain by deleting the first consensus cysteine or proteasome inhibitor treatment significantly diminished the effect of TRIM11 on the intracellular level of HN [2].
  • The intracellular level of glutathione S-transferase-fused or EGFP-fused HN peptides or plain HN was drastically reduced by the coexpression of TRIM11 [2].

Physical interactions of TRIM11


Other interactions of TRIM11


  1. TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. Ishikawa, H., Tachikawa, H., Miura, Y., Takahashi, N. FEBS Lett. (2006) [Pubmed]
  2. A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Niikura, T., Hashimoto, Y., Tajima, H., Ishizaka, M., Yamagishi, Y., Kawasumi, M., Nawa, M., Terashita, K., Aiso, S., Nishimoto, I. Eur. J. Neurosci. (2003) [Pubmed]
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