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Gene Review:

KCNK16 - potassium channel, two pore domain...

Homo sapiens

Synonyms: 2P domain potassium channel Talk-1, K2p16.1, Potassium channel subfamily K member 16, TALK-1, TALK1, ...

Duprat, F. et al., Han, J. et al., Girard, C. et al.

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High impact information on KCNK16

Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species [1].
We identified and characterized three novel splice variants of TALK-1 from human pancreas [2].

Anatomical context of KCNK16

TALK-1 is exclusively expressed in the pancreas [3].

Analytical, diagnostic and therapeutic context of KCNK16

Northern blot analysis showed that among the 15 tissues examined, TALK-1 was expressed mainly in the pancreas [2].
This study firstly shows with in situ hybridization on human pancreas that TALK-1 and TALK-2, two members of the 2P domain potassium channel (K(2P)) family, are highly and specifically expressed in the exocrine pancreas and absent in Langherans islets [1].

References

Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. Duprat, F., Girard, C., Jarretou, G., Lazdunski, M. J. Physiol. (Lond.) (2005) [Pubmed]
Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. Han, J., Kang, D., Kim, D. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Girard, C., Duprat, F., Terrenoire, C., Tinel, N., Fosset, M., Romey, G., Lazdunski, M., Lesage, F. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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