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SLC25A11  -  solute carrier family 25 (mitochondrial...

Homo sapiens

Synonyms: Mitochondrial 2-oxoglutarate/malate carrier protein, OGC, OGCP, SLC20A4, Solute carrier family 25 member 11
 
 
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Disease relevance of SLC25A11

 

High impact information on SLC25A11

  • Surprisingly, overexpression of the human 2-oxoglutarate carrier (OGC) protein (originally designed as a negative control) sparked a significant drop in Deltapsi(m), possibly signalling a previously unappreciated uncoupling activity for the OGC [2].
  • We have studied the targeting and assembly of the 2-oxoglutarate carrier (OGC), an integral inner-membrane protein of mitochondria [3].
  • The oxoglutarate carrier (OGC) purified from bovine heart mitochondria was treated, both in its active and in its SDS-denatured state, with the fluorescent N-(1-pyrenyl)maleimide and other SH reagents before and after reduction with dithioerythritol or beta-mercaptoethanol [4].
  • The identity and function of specific carrier proteins in other tissues is less certain, although the OGC is expressed in heart, liver, and brain and the DIC is expressed in liver and kidney [5].
  • Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3 [6].
 

Biological context of SLC25A11

  • Overexpression of the cDNA for the DIC and OGC in a renal proximal tubule-derived cell line, NRK-52E cells, showed that enhanced carrier expression and activity protects against oxidative stress and chemically induced apoptosis [5].
 

Anatomical context of SLC25A11

  • Import of the mammalian OGC occurs efficiently into both mammalian and yeast mitochondria [3].
 

Associations of SLC25A11 with chemical compounds

References

  1. Comparison of intravenous methylprednisolone therapy vs. oral methylprednisolone therapy in patients with Graves' ophthalmopathy. Aktaran, S., Akarsu, E., Erbağci, I., Araz, M., Okumuş, S., Kartal, M. International journal of clinical practice (2007) [Pubmed]
  2. Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69. Yu, X.X., Lewin, D.A., Zhong, A., Brush, J., Schow, P.W., Sherwood, S.W., Pan, G., Adams, S.H. Biochem. J. (2001) [Pubmed]
  3. Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane. Palmisano, A., Zara, V., Hönlinger, A., Vozza, A., Dekker, P.J., Pfanner, N., Palmieri, F. Biochem. J. (1998) [Pubmed]
  4. The mitochondrial oxoglutarate carrier protein contains a disulfide bridge between intramembranous cysteines 221 and 224. Bisaccia, F., Capobianco, L., Mazzeo, M., Palmieri, F. FEBS Lett. (1996) [Pubmed]
  5. Mitochondrial glutathione transport: Physiological, pathological and toxicological implications. Lash, L.H. Chem. Biol. Interact. (2006) [Pubmed]
  6. Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3. Piccininni, S., Iacobazzi, V., Lauria, G., Rocchi, M., Palmieri, F. Cytogenet. Cell Genet. (1998) [Pubmed]
  7. The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier. Bisaccia, F., Zara, V., Capobianco, L., Iacobazzi, V., Mazzeo, M., Palmieri, F. Biochim. Biophys. Acta (1996) [Pubmed]
 
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