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Gene Review

C15orf48  -  chromosome 15 open reading frame 48

Homo sapiens

Synonyms: FOAP-11, NMES1, Normal mucosa of esophagus-specific gene 1 protein, Protein FOAP-11
 
 
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Disease relevance of C15orf48

  • A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma [1].
  • CONCLUSION: Data suggest that perc-NMES is less painful than trans-NMES in the treatment of shoulder subluxation in hemiplegia [2].
  • Although preliminary, this pattern of results suggests that combined NMES/TENS may be a valuable adjunct in the management of chronic back pain [3].
 

Psychiatry related information on C15orf48

  • The 1985-86 data from 308 children and young adults under age 25 with autism and from 326 with severe or profound mental retardation can be compared to national data from the 1980 MNCUES and the 1987 NMES because the methods are similar [4].
 

High impact information on C15orf48

  • Immunohistochemistry confirmed the downregulation of NMES1 in esophageal SCC at the protein level and showed that it is a nuclear protein [1].
  • The negative correlation of NMES1 expression with esophageal oncogenesis suggests its suppressive role in tumorigenesis of the esophagus, while the precise function of NMES1 still needs further investigation [1].
  • Musculo-skeletal modelling of NMES-evoked knee extension in spinal cord injury [5].
  • OBJECTIVE: To investigate the feasibility of percutaneous intramuscular neuromuscular electric stimulation (perc-NMES) for treating shoulder subluxation and pain in patients with chronic hemiplegia [6].
  • CONCLUSIONS: Perc-NMES is feasible for treating shoulder dysfunction in hemiplegia and may reduce shoulder subluxation, reduce pain, improve range of motion, enhance motor recovery, and reduce disability in patients with chronic hemiplegia and shoulder subluxation [6].
 

Analytical, diagnostic and therapeutic context of C15orf48

  • Northern blot showed that NMES1 was distributed mainly in the alimentary tract [1].
  • DATA SOURCES/STUDY DESIGN: Cross-sectional data from the National Health Interview Survey (NHIS), National Health and Nutrition Examination Survey (NHANES), and National Health Expenditure surveys (NMCES, NMES, MEPS) [7].
  • The purpose of this study is to test the same set of models of medical use using identically measured predictor variables in three nationally representative data sets of older Americans: 1984 Study of Aging (SOA); 1984 National Long-Term Care Survey (NLTC); and the 1987 National Medical Care Expenditure Survey (NMES) [8].
  • Intramuscular EMG-controlled NMES may be superior to transcutaneous systems and is presently undergoing preliminary randomized clinical trials [9].
  • CONCLUSIONS: NMES data show that dental care expenditures are considerable, almost as large as expenditures for office-based medical care, and are a significant component of all nonhospital health care expenditures for noninstitutionalized Americans [10].

References

  1. A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma. Zhou, J., Wang, H., Lu, A., Hu, G., Luo, A., Ding, F., Zhang, J., Wang, X., Wu, M., Liu, Z. Int. J. Cancer (2002) [Pubmed]
  2. Comparing stimulation-induced pain during percutaneous (intramuscular) and transcutaneous neuromuscular electric stimulation for treating shoulder subluxation in hemiplegia. Yu, D.T., Chae, J., Walker, M.E., Hart, R.L., Petroski, G.F. Archives of physical medicine and rehabilitation. (2001) [Pubmed]
  3. Combined neuromuscular electrical stimulation and transcutaneous electrical nerve stimulation for treatment of chronic back pain: a double-blind, repeated measures comparison. Moore, S.R., Shurman, J. Archives of physical medicine and rehabilitation. (1997) [Pubmed]
  4. Health care financing for severe developmental disabilities. Birenbaum, A., Guyot, D., Cohen, H.J. Monographs of the American Association on Mental Retardation. (1990) [Pubmed]
  5. Musculo-skeletal modelling of NMES-evoked knee extension in spinal cord injury. Sinclair, P.J., Davis, G.M., Smith, R.M. Journal of biomechanics. (2006) [Pubmed]
  6. Percutaneous intramuscular neuromuscular electric stimulation for the treatment of shoulder subluxation and pain in patients with chronic hemiplegia: a pilot study. Yu, D.T., Chae, J., Walker, M.E., Fang, Z.P. Archives of physical medicine and rehabilitation. (2001) [Pubmed]
  7. Comparing oral health care utilization estimates in the United States across three nationally representative surveys. Macek, M.D., Manski, R.J., Vargas, C.M., Moeller, J.F. Health services research. (2002) [Pubmed]
  8. Use of medical care by African American and White older persons: comparative analysis of three national data sets. Miller, B., Campbell, R.T., Furner, S., Kaufman, J.E., Li, M., Muramatsu, N., Prohaska, T. The journals of gerontology. Series B, Psychological sciences and social sciences. (1997) [Pubmed]
  9. Neuromuscular electrical stimulation for motor relearning in hemiparesis. Chae, J. Physical medicine and rehabilitation clinics of North America. (2003) [Pubmed]
  10. A comparison of dental care expenditures and office-based medical care expenditures, 1987. Manski, R.J., Moeller, J.F., Maas, W.R. Journal of the American Dental Association (1939) (1999) [Pubmed]
 
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