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Gene Review

AAP1  -  Aap1p

Saccharomyces cerevisiae S288c

Synonyms: Alanine/arginine aminopeptidase, YHR047C
 
 
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High impact information on AAP1

  • We identified a novel protein, AAP1 (ABL-associated protein 1), that associates with these c-ABL domains and fails to bind to the SH3 domain in the activated oncoprotein BCRABL [1].
  • Although AAP1 and AAP8 originate from a duplicated region on chromosome I, biochemical properties and expression pattern diverged [2].
  • Strains carrying the AAP1 gene on a high copy plasmid show an increase in the major arginine/alanine aminopeptidase activity, a dramatic increase in glycogen accumulation, and an increase in transcription from a vector carrying lacZ fused to the promoter of a gene (SSA3) expressed during post-diauxic and stationary phases of the culture cycle [3].
  • Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast [3].
  • Insertional inactivation of the AAP1 gene resulted in a decrease in glycogen accumulation and the loss of the major band of arginine/alanine aminopeptidase activity [3].
 

Biological context of AAP1

 

Associations of AAP1 with chemical compounds

References

  1. c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein. Zhu, J., Shore, S.K. Mol. Cell. Biol. (1996) [Pubmed]
  2. High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis. Okumoto, S., Schmidt, R., Tegeder, M., Fischer, W.N., Rentsch, D., Frommer, W.B., Koch, W. J. Biol. Chem. (2002) [Pubmed]
  3. Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast. Caprioglio, D.R., Padilla, C., Werner-Washburne, M. J. Biol. Chem. (1993) [Pubmed]
  4. Differential expression of two related amino acid transporters with differing substrate specificity in Arabidopsis thaliana. Kwart, M., Hirner, B., Hummel, S., Frommer, W.B. Plant J. (1993) [Pubmed]
 
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