Gene Review:
H1FX - H1 histone family, member X
Homo sapiens
Synonyms:
H1.10, H1X, Histone H1x, MGC15959, MGC8350
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High impact information on H1FX
- By the time of chromosome condensation, pronuclear histones comprised H1X, H2A.X, H2B, H3, and H4 [1].
- During embryonic development, H1X persisted in the nuclei up to the blastula stage, but mostly disappeared at the gastrula stage concomitant with the appearance of H1 subtypes of differentiated cells and the replacement of H2A.X by H2A [1].
- This protein, designated as H1X, was regarded as an H1 subtype on the basis of its solubility in acids or salt and its lysine-rich amino acid composition [1].
Analytical, diagnostic and therapeutic context of H1FX
- Peptide mapping using V8 protease further indicated that H1X is not a post-transcriptionally modified form of other somatic type H1 histones [1].
References
- Occurrence of H1 subtypes specific to pronuclei and cleavage-stage cell nuclei of anuran amphibians. Ohsumi, K., Katagiri, C. Dev. Biol. (1991) [Pubmed]
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