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Gene Review: 

RAB11B  -  RAB11B, member RAS oncogene family

Homo sapiens

Synonyms: GTP-binding protein YPT3, H-YPT3, MGC133246, Ras-related protein Rab-11B, YPT3
 
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High impact information on RAB11B

  • A cDNA clone from tomato fruit encodes a protein with strong homology with the rab11/YPT3 class of small GTPases that is thought to be involved in the control of protein trafficking within cells [1].
  • Green fluorescent protein (GFP)-tagged Ypt3 showed cytoplasmic staining that was concentrated at growth sites, and this polarized localization required the actin cytoskeleton [2].
 

Other interactions of RAB11B

  • The one homologous to rab/YPT, referred to here as YL8, appears to be the human homolog of the recently reported Schizosaccharomyces pombe YPT3 gene [3].

References

  1. Developmental abnormalities and reduced fruit softening in tomato plants expressing an antisense Rab11 GTPase gene. Lu, C., Zainal, Z., Tucker, G.A., Lycett, G.W. Plant Cell (2001)
  2. Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function. Cheng, H., Sugiura, R., Wu, W., Fujita, M., Lu, Y., Sio, S.O., Kawai, R., Takegawa, K., Shuntoh, H., Kuno, T. Mol. Biol. Cell (2002)
  3. Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. Drivas, G.T., Shih, A., Coutavas, E.E., D'Eustachio, P., Rush, M.G. Oncogene (1991)
 

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