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TIMM50  -  translocase of inner mitochondrial...

Homo sapiens

Synonyms: Mitochondrial import inner membrane translocase subunit TIM50, PRO1512, TIM50, TIM50L
 
 
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High impact information on TIMM50

  • Tim50 is anchored to the inner mitochondrial membrane, exposing the C-terminal domain to the intermembrane space [1].
  • Functional defects of Tim50 either by depletion of the protein or addition of anti-Tim50 antibodies block the protein translocation across the inner membrane [1].
  • Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death [2].
  • RESULTS: In this report, we identify a minor isoform of the mitochondrial Tim50, Tim50a, as a coilin interacting protein [3].
  • Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis [3].
 

Anatomical context of TIMM50

  • These observations indicate that loss of Tim50 in vertebrates causes mitochondrial membrane permeabilization and dysfunction followed by cytoplasmic release of cytochrome c along with other mitochondrial inducers of cell death [2].
  • In contrast to Tim50, which localizes to the cytoplasm and mitochondria, Tim50a is strictly nuclear and is enriched in speckles with snRNPs [3].

References

  1. Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. Yamamoto, H., Esaki, M., Kanamori, T., Tamura, Y., Nishikawa, S., Endo, T. Cell (2002) [Pubmed]
  2. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. Guo, Y., Cheong, N., Zhang, Z., De Rose, R., Deng, Y., Farber, S.A., Fernandes-Alnemri, T., Alnemri, E.S. J. Biol. Chem. (2004) [Pubmed]
  3. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. Xu, H., Somers, Z.B., Robinson, M.L., Hebert, M.D. BMC Cell Biol. (2005) [Pubmed]
 
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