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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TAAR2  -  trace amine associated receptor 2

Homo sapiens

Synonyms: G-protein coupled receptor 58, GPR58, TaR-2, Trace amine receptor 2, Trace amine-associated receptor 2, ...
 
 
 
 
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High impact information on TAAR2

  • Based on shared sequence identities, the receptor encoded by GPR57 was predicted to belong to a novel subfamily of GPCRs together with GPR58 (a.k.a. phBL5, reported only in the patent literature), putative neurotransmitter receptor (PNR) and a 5-HT(4) pseudogene [1].
  • PNR and GPR58 were expressed in COS cells, however no specific binding was observed for various serotonin receptor-specific ligands [1].
  • Furthermore, psiGPR57, GPR58, PNR and the 5-HT(4) pseudogene were mapped in a cluster localized to chromosome 6q22-24 [1].

References

  1. Cloning and characterization of additional members of the G protein-coupled receptor family. Lee, D.K., Lynch, K.R., Nguyen, T., Im, D.S., Cheng, R., Saldivia, V.R., Liu, Y., Liu, I.S., Heng, H.H., Seeman, P., George, S.R., O'Dowd, B.F., Marchese, A. Biochim. Biophys. Acta (2000) [Pubmed]
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