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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Trim16  -  tripartite motif-containing 16

Mus musculus

Synonyms: 9130006M08Rik, AI482483, EBBP, Ebbp, Estrogen-responsive B box protein, ...
 
 
 
 
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High impact information on Trim16

  • Stable overexpression of EBBP in HaCaT keratinocytes did not affect the proliferation rate of the transfected cells, but enhanced the early differentiation process [1].
  • These results suggest that the presence of EBBP in basal keratinocytes is important for the differentiation capacity of these cells, and that down-regulation of EBBP expression in a hyperproliferative epithelium is required to maintain the cells in a non-differentiated stage [1].

References

  1. The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation. Beer, H.D., Munding, C., Dubois, N., Mamie, C., Hohl, D., Werner, S. J. Biol. Chem. (2002) [Pubmed]
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