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Gene Review

ffh  -  Signal Recognition Particle (SRP)...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2607, JW5414
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Disease relevance of ffh

  • Sequence comparisons, however, have identified (i) a gene in Escherichia coli (ffh) whose product is homologous to the 54-kilodalton subunit (SRP54) of SRP, and (ii) an RNA encoded by the ffs gene (4.5S RNA) that shares a conserved domain with the 7SL RNA of SRP [1].

High impact information on ffh

  • Here we address this issue directly by construction of a strain in which ffh expression is arabinose-dependent [2].
  • Functional analysis of the ffh-trmD region of the Escherichia coli chromosome by using reverse genetics [3].
  • We also examined the interference of pilA expression in E. coli with the function of the products of ftsY and ffh and observed an accumulation of pre-beta-lactamase [4].

Biological context of ffh

  • Pulse-chase labeling experiments indicated that Ffh protein is unstable in cells carrying ffh on high-copy-number plasmids and that simultaneous overproduction of 4.5S RNA stabilizes Ffh protein [5].

Regulatory relationships of ffh

  • The mutant also shows elevated expression of heat shock proteins and accumulates insoluble proteins, especially at 42 degrees C. It was further observed that the temperature sensitivity of the ffh mutant was suppressed by overproduction of 4.5S RNA, the RNA component of the bacterial SRP, by stabilizing the thermolabile protein [6].


  1. An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Poritz, M.A., Bernstein, H.D., Strub, K., Zopf, D., Wilhelm, H., Walter, P. Science (1990) [Pubmed]
  2. The E. coli ffh gene is necessary for viability and efficient protein export. Phillips, G.J., Silhavy, T.J. Nature (1992) [Pubmed]
  3. Functional analysis of the ffh-trmD region of the Escherichia coli chromosome by using reverse genetics. Persson, B.C., Bylund, G.O., Berg, D.E., Wikström, P.M. J. Bacteriol. (1995) [Pubmed]
  4. Role of pilA, an essential regulatory gene of Neisseria gonorrhoeae, in the stress response. Taha, M.K., Larribe, M., Dupuy, B., Giorgini, D., Marchal, C. J. Bacteriol. (1992) [Pubmed]
  5. Concentrations of 4.5S RNA and Ffh protein in Escherichia coli: the stability of Ffh protein is dependent on the concentration of 4.5S RNA. Jensen, C.G., Pedersen, S. J. Bacteriol. (1994) [Pubmed]
  6. Functional analysis of the signal recognition particle in Escherichia coli by characterization of a temperature-sensitive ffh mutant. Park, S.K., Jiang, F., Dalbey, R.E., Phillips, G.J. J. Bacteriol. (2002) [Pubmed]
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