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Gene Review

POLR1C  -  polymerase (RNA) I polypeptide C, 30kDa

Homo sapiens

Synonyms: AC40, DNA-directed RNA polymerase I subunit C, DNA-directed RNA polymerases I and III 40 kDa polypeptide, DNA-directed RNA polymerases I and III subunit RPAC1, POLR1E, ...
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High impact information on POLR1C

  • Deficient transcription of subunit RPA 40 of RNA polymerase I and III in heart of rats with neonatal asphyxia [1].
  • Both RNA polymerases form ribosomal biogenesis in a concerted action and have a common subunit, RPA40, essential for function and integrity [1].
  • There was a direct proportional relationship between the pulmonary valve annulus diameter and the cube root of the right ventricular volume (r = 0.952), as well as between SV and cross-sections of the right pulmonary artery (RPAC; r = 0.916), left pulmonary artery (LPAC; r = 0.878) and descending thoracic aorta (r = 0.962) [2].

Other interactions of POLR1C


Analytical, diagnostic and therapeutic context of POLR1C

  • Rat pups were exposed to various asphyctic periods up to twenty minutes and heart tissue was taken for the evaluation of mRNA RPA40 levels, pH measurements and histological evaluation of the nucleolus by silver staining. mRNA RPA40 levels gradually decreased with the length of the asphyctic period paralleling the decrease of pH [1].


  1. Deficient transcription of subunit RPA 40 of RNA polymerase I and III in heart of rats with neonatal asphyxia. Hoeger, H., Labudova, O., Mosgoeller, W., Herrera-Marschitz, M., Fuerst, G., Kitzmüller, E., Lubec, B. Life Sci. (1998) [Pubmed]
  2. Dimensions of the great arteries, semilunar valve roots, and right ventricular outflow tract during growth: normative angiocardiographic data. Sievers, H.H., Onnasch, D.G., Lange, P.E., Bernhard, A., Heintzen, P.H. Pediatric cardiology. (1983) [Pubmed]
  3. Cloning and characterization of the human RNA polymerase I subunit hRPA40. Dammann, R., Pfeifer, G.P. Biochim. Biophys. Acta (1998) [Pubmed]
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