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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PJA2  -  praja ring finger 2, E3 ubiquitin protein...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase Praja-2, KIAA0438, Neurodap1, Praja2, RING finger protein 131, ...
 
 
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High impact information on PJA2

  • Among them, we focus on one downregulated gene, named Neurodap1, because this gene encodes a novel protein carrying the RING-H2 sequence motif categorized in the zinc finger family [1].
  • Therefore, Neurodap1, a newly identified protein as an axotomy-suppressed gene product, might play a significant role in synaptic communication and plasticity through the control of the formation of PSD for maintaining vital functions of nerve cells [1].
  • Amino acid sequence analysis of the 71-kDa protein PJA1 showed 52.3% identity to human PJA2 (for praja-2, also known as NEURODAP1/KIAA0438) and also a significant identity to its homologs in rat, mouse, and zebrafish [2].

References

  1. A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse. Nakayama, M., Miyake, T., Gahara, Y., Ohara, O., Kitamura, T. J. Neurosci. (1995) [Pubmed]
  2. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. Yu, P., Chen, Y., Tagle, D.A., Cai, T. Genomics (2002) [Pubmed]
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