Disease relevance of CLEC2B

• In continuous ambulatory ECG recordings, AICL occurred hours before spontaneous initiation of sustained atrial and ventricular arrhythmias in different patient populations [1].

High impact information on CLEC2B

• 1. Chloride-sensitive double-barrelled microelectrodes were used to measure the intracellular Cl- activity (aicl) and membrane potential (Em) in neuropile glial cells of the leech, Hirudo medicinalis [2].
• We herein report the cDNA cloning of a new molecule, designated activation-induced C-type lectin (AICL), whose gene maps to the human NK gene complex proximal to the CD69 gene [3].
• 5. The presence of AICL transcripts in different cell types of hematopoietic origin, a rapid increase of gene transcription during lymphocyte activation, and a short half-life of the mRNA characterize AICL as a new, broadly expressed activation antigen [3].
• Two full genes of the five fragments were cloned, which activation-induced C-type lectin and glucose transporter-like protein [4].
• Time-frequency analysis of the most significant eigenvectors of cardiac rhythm in subjects undergoing head-up tilt showed that AICL could indicate instabilities and unsuccessful adaptation of autonomic nervous system activity to physiological stimuli [1].

Anatomical context of CLEC2B

• Open tip and Cl(-)-selective microelectrodes were used to study the effects of cAMP on apical membrane potential (Va), fractional voltage ratio (fa) and intracellular chloride activity (aicl) in Necturus gallbladder under open-circuit conditions [5].

Associations of CLEC2B with chemical compounds

• CHX treatment resulted also in an overexpression of AICL, LLT1, and CD161/NKR-P1A mRNAs [6].

References