Association of human cyclin E with a periodic G1-S phase protein kinase.
G1 cyclins control the G1 to S phase transition in the budding yeast, Saccharomyces cerevisiae. Cyclin E was discovered in the course of a screen for human complementary DNAs that rescue a deficiency of G1 cyclin function in budding yeast. The amounts of both the cyclin E protein and an associated protein kinase activity fluctuated periodically through the human cell cycle; both were maximal in late G1 and early S phases. Cyclin E- associated kinase activity was correlated with the appearance of complexes containing cyclin E and the cyclin-dependent kinase Cdk2. Thus, the cyclin E- Cdk2 complex may constitute a human G1-S phase-specific regulatory protein kinase.[1]References
- Association of human cyclin E with a periodic G1-S phase protein kinase. Dulić, V., Lees, E., Reed, S.I. Science (1992) [Pubmed]
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