- Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. Xu, Q., Takekida, S., Ohara, N., Chen, W., Sitruk-Ware, R., Johansson, E.D., Maruo, T. J. Clin. Endocrinol. Metab. (2005)