- BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. Angeletti, B., Waldron, K.J., Freeman, K.B., Bawagan, H., Hussain, I., Miller, C.C., Lau, K.F., Tennant, M.E., Dennison, C., Robinson, N.J., Dingwall, C. J. Biol. Chem. (2005)