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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Negative Regulation of T Cell Activation and Autoimmunity by the Transmembrane Adaptor Protein LAB.

LAB (linker for activation of B cells), also known as NTAL (non-T cell activation linker), is a LAT (linker for activation of T cells)-like adaptor protein that is expressed in B, NK, and mast cells. Its role in lymphocytes has not been clearly demonstrated. Here, we showed that aged LAB-deficient (Lat2(-/-)) mice developed an autoimmune syndrome. Lat2(-/-) T cells were hyperactivated and produced more cytokines than Lat2(+/+) T cells. Even though LAB was absent in naive T cells, LAB could be detected in activated Lat2(+/+) T cells. LAT- mediated signaling events were enhanced in Lat2(-/-) T cells; however, they were suppressed in T cells that overexpressed LAB. Mice with the Lat2 gene conditionally deleted from T cells also developed the autoimmune syndrome like Lat2(-/-) mice. Together, these data demonstrated an important role of LAB in limiting autoimmune response and exposed a mechanism regulating T cell activation.[1]

References

  1. Negative Regulation of T Cell Activation and Autoimmunity by the Transmembrane Adaptor Protein LAB. Zhu, M., Koonpaew, S., Liu, Y., Shen, S., Denning, T., Dzhagalov, I., Rhee, I., Zhang, W. Immunity (2006) [Pubmed]
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