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O'Bryant, S.E. et al.

Sid E. O'Bryant, Jed Falkowski, Valerie Hobson, Leigh Johnson, James Hall, Gregory W. Schrimsher, Ohmar Win, Bichthy Ngo, Andrew Dentino,

Executive functioning mediates the link between other neuropsychological domains and daily functioning: a Project FRONTIER study.

BACKGROUND: The purpose of this study was to examine the mediating impact of executive functioning on the link between other neuropsychological domain scores and informant-based rating of functional status. METHODS: Data on 181 participants were analyzed from an ongoing epidemiological study of rural health, Project FRONTIER (mean age = 64.6 ± 13.8 years, 69% women, 42% Mexican American). Executive functioning was assessed by the EXIT25 and other neuropsychological domains were assessed via the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Informant-based rating of functional status was assessed via the Clinical Dementia Rating Scale sum of boxes scores (CDR SB). RESULTS: RBANS Index scores were each significantly (p < 0.05) related to CDR SB scores and EXIT25 scores. EXIT25 score was a significant partial mediator of the link between four RBANS indices (Immediate Memory, Attention, Visuospatial/Construction, Delayed Memory) and CDR SB scores, and a complete mediator of the fifth index (Language). CONCLUSION: Executive functioning is a mediator of the link between other neuropsychological domains and daily functioning. Neuropsychological assessments that do not measure executive functioning will provide only a partial clinical picture with adults and elders.[1]

References

Executive functioning mediates the link between other neuropsychological domains and daily functioning: a Project FRONTIER study. O'Bryant, S.E., Falkowski, J., Hobson, V., Johnson, L., Hall, J., Schrimsher, G.W., Win, O., Ngo, B., Dentino, A. Int. Psychogeriatr (2011) [Pubmed]

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