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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A specific inhibition of induction of adaptive response by o-vanillin, a potent comutagen.

The present study revealed that potent comutagenic activity of o-vanillin in mutagenesis by N-methyl-N-nitrosourea (MNU) is a consequence of inhibition of the transcriptional promoting capacity of methylated O6-methylguanine-DNA methyltransferase (MGTase). As evidence of this, in the presence of o-vanillin, there were (i) dose-dependent decreases in MGTase induced in E. coli exposed to MNU, (ii) inhibition of ada gene promotion determined in the ada'-lacZ' assay system, and (iii) minimal inhibition of the methyl transfer capacity of MGTase in a subcellular system.[1]

References

  1. A specific inhibition of induction of adaptive response by o-vanillin, a potent comutagen. Takahashi, K., Sekiguchi, M., Kawazoe, Y. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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