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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effect of cyclophosphamide therapy on oncogene expression in angioimmunoblastic lymphadenopathy.

The expression of four cellular oncogenes was studied by means of northern blot analysis of messenger RNA in peripheral-blood mononuclear cells from patients with angioimmunoblastic lymphadenopathy (AILD). On average, cells from patients with AILD and from those with systemic lupus erythematosus ( SLE) expressed significantly more N-ras and significantly less c-fos mRNA than did cells from healthy controls. Expression of these cellular oncogenes was most abnormal in patients with the most severe disease. In contrast, increased levels of c-myc mRNA were found in patients with SLE but not in those with AILD. Administration of cyclophosphamide to patients with AILD was followed by return to normal of both N-ras and c-fos expression.[1]

References

  1. Effect of cyclophosphamide therapy on oncogene expression in angioimmunoblastic lymphadenopathy. Klinman, D.M., Steinberg, A.D., Mushinski, J.F. Lancet (1986) [Pubmed]
 
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