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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Polymorphic DNA marker on X chromosome and manic depression.

Heredity is an important factor in vulnerability to manic depression. A genetic linkage has been demonstrated between manic depression and coagulation factor IX at Xq27 with a TaqI polymorphism at the F9 locus in DNA samples from peripheral leucocytes of manic depressive probands and relatives in 10 informative families. Statistical analysis of the pedigrees gave a maximum lod score of 3.10 at a recombination fraction of 0.11, demonstrating a linkage between a manic depressive locus and the F9 locus in the Xq27 region.[1]

References

  1. Polymorphic DNA marker on X chromosome and manic depression. Mendlewicz, J., Simon, P., Sevy, S., Charon, F., Brocas, H., Legros, S., Vassart, G. Lancet (1987) [Pubmed]
 
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