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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Electron microscopic demonstration of a supraependymal cluster of neuronal cells and processes in the hamster third ventricle.

A supraependymal cluster of neuronal cells and processes consistently present on the floor of the hamster third ventricle was identified and characterized by means of correlative scanning (SEM) and transmission ( TEM) electron microscopy. SEM revealed each cluster to be ovoid with the majority of its surface covered by dome-shaped protrusions and fine beaded fibers. A number of processes traveling individually or in groups also entered or exited from the cluster at its base. As these processes passed over the ventricular surface, they contributed to an extensive network on the floor and ventral aspect of the ventricular wall. Some processes terminated on the ependymal surface in bulbous endings while others penetrated the ependyma. The neuronal nature of these clusters and their associated processes was confirmed at the TEM level. The dome-shaped protrusions visible on the surface of the cluster in SEM corresponded to apical surfaces of neurons confined to the peripheral aspect of a core of loosely arranged processes. These cells exhibited a prominent nucleolus, stacks of rough endoplasmic reticulum (RER), polyribosomes, Golgi cisternae, mitochondria and microtubules (MT) and gave rise to dendritic processes which extended into the core. These dendrites gave off branches at acute angles and contained polyribosomes, single cisternae of RER and evenly spaced MT. Other profiles of processes within the core shared these characteristics, suggesting that they also were branches of the peripheral cells. Axons present within the core and on the cluster's surface exhibited vesicle-filled varicosities which frequently established synaptic contact with the peripheral cells and their processes. The presence of an intraventricular cluster of neurons which potentially communicates with centers extrinsic to the ventricle may have important implications in the hypothesized role of cerebrospinal fluid and tanycytic ependyma in the neuroendocrine regulation of anterior pituitary function.[1]

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