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R.J. Mathvink

Department of Medicinal Chemistry

Merck Research Laboratories

Rahway

NJ 07065

USA

[email]@merck.com

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Affiliations

Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. 2000
Merck Research Laboratories, Rahway, New Jersey 07065, USA. 2000

References

Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore. Mathvink, R.J., Tolman, J.S., Chitty, D., Candelore, M.R., Cascieri, M.A., Colwell, L.F., Deng, L., Feeney, W.P., Forrest, M.J., Hom, G.J., MacIntyre, D.E., Tota, L., Wyvratt, M.J., Fisher, M.H., Weber, A.E. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide. Mathvink, R.J., Tolman, J.S., Chitty, D., Candelore, M.R., Cascieri, M.A., Colwell, L.F., Deng, L., Feeney, W.P., Forrest, M.J., Hom, G.J., MacIntyre, D.E., Miller, R.R., Stearns, R.A., Tota, L., Wyvratt, M.J., Fisher, M.H., Weber, A.E. J. Med. Chem. (2000) [Pubmed]