R.M. McKernan
Neuroscience Research Centre
Merck Sharp and Dohme Research Laboratories
Terlings Park
Eastwick Road
UK
Name/email consistency: high
- Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. McKernan, R.M., Rosahl, T.W., Reynolds, D.S., Sur, C., Wafford, K.A., Atack, J.R., Farrar, S., Myers, J., Cook, G., Ferris, P., Garrett, L., Bristow, L., Marshall, G., Macaulay, A., Brown, N., Howell, O., Moore, K.W., Carling, R.W., Street, L.J., Castro, J.L., Ragan, C.I., Dawson, G.R., Whiting, P.J. Nat. Neurosci. (2000)
- Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these within the benzodiazepine pharmacophore. McKernan, R.M., Farrar, S., Collins, I., Emms, F., Asuni, A., Quirk, K., Broughton, H. Mol. Pharmacol. (1998)