Birgitte Holst
Laboratory for Molecular Pharmacology
The Panum Institute
University of Copenhagen
Blegdamsvej 3
Denmark
Name/email consistency: high
- Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor. Holst, B., Frimurer, T.M., Mokrosinski, J., Halkjaer, T., Cullberg, K.B., Underwood, C.R., Schwartz, T.W. Mol. Pharmacol. (2009)
- Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. Holst, B., Mokrosinski, J., Lang, M., Brandt, E., Nygaard, R., Frimurer, T.M., Beck-Sickinger, A.G., Schwartz, T.W. J. Biol. Chem. (2007)
- Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor. Holst, B., Lang, M., Brandt, E., Bach, A., Howard, A., Frimurer, T.M., Beck-Sickinger, A., Schwartz, T.W. Mol. Pharmacol. (2006)
- Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Holst, B., Brandt, E., Bach, A., Heding, A., Schwartz, T.W. Mol. Endocrinol. (2005)
- Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Holst, B., Schwartz, T.W. Trends Pharmacol. Sci. (2004)
- Common structural basis for constitutive activity of the ghrelin receptor family. Holst, B., Holliday, N.D., Bach, A., Elling, C.E., Cox, H.M., Schwartz, T.W. J. Biol. Chem. (2004)
- Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe. Holst, B., Schwartz, T.W. Ann. N. Y. Acad. Sci. (2003)
- High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. Holst, B., Cygankiewicz, A., Jensen, T.H., Ankersen, M., Schwartz, T.W. Mol. Endocrinol. (2003)
- Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. Holst, B., Elling, C.E., Schwartz, T.W. J. Biol. Chem. (2002)