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Santosh Kumar

Department of Pharmacology and Toxicology

University of Texas Medical Branch

301 University Boulevard




Name/email consistency: high



  • Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, USA. 2003 - 2007


  1. Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution. Kumar, S., Zhao, Y., Sun, L., Negi, S.S., Halpert, J.R., Muralidhara, B.K. Mol. Pharmacol. (2007) [Pubmed]
  2. Identification of a novel laser dye substrate of mammalian cytochromes P450: application in rapid kinetic analysis, inhibitor screening, and directed evolution. Kumar, S. J. Biomol. Screen (2007) [Pubmed]
  3. Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Kumar, S., Liu, H., Halpert, J.R. Drug Metab. Dispos. (2006) [Pubmed]
  4. Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide. Kumar, S., Sun, L., Liu, H., Muralidhara, B.K., Halpert, J.R. Protein Eng. Des. Sel. (2006) [Pubmed]
  5. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. Kumar, S., Chen, C.S., Waxman, D.J., Halpert, J.R. J. Biol. Chem. (2005) [Pubmed]
  6. Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity. Kumar, S., Davydov, D.R., Halpert, J.R. Drug Metab. Dispos. (2005) [Pubmed]
  7. Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts. Kumar, S., Halpert, J.R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5. Kumar, S., Scott, E.E., Liu, H., Halpert, J.R. J. Biol. Chem. (2003) [Pubmed]
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