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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sheo B. Singh

Merck Research Laboratories

xDPS, 126 E. Lincoln Ave.




Name/email consistency: high



  • Merck Research Laboratories, xDPS, 126 E. Lincoln Ave., RY33-612, USA. 2007 - 2010
  • Merck Research Laboratories, Rahway, New Jersey 07065, USA. 2000 - 2009
  • Merck & Co Inc, PO Box 2000, Building RY80Y-355, Rahway, USA. 2002


  1. New antibiotic structures from fermentations. Singh, S.B., Young, K. Expert. Opin. Ther. Pat (2010) [Pubmed]
  2. Isolation, structure, and antibacterial activities of lucensimycins D-G, discovered from Streptomyces lucensis MA7349 using an antisense strategy. Singh, S.B., Zink, D.L., Dorso, K., Motyl, M., Salazar, O., Basilio, A., Vicente, F., Byrne, K.M., Ha, S., Genilloud, O. J. Nat. Prod. (2009) [Pubmed]
  3. Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Singh, S.B., Ondeyka, J.G., Herath, K.B., Zhang, C., Jayasuriya, H., Zink, D.L., Parthasarathy, G., Becker, J.W., Wang, J., Soisson, S.M. Bioorg. Med. Chem. Lett. (2009) [Pubmed]
  4. Anthelmintic macrolactams from Nonomuraea turkmeniaca MA7381. Ayers, S., Zink, D.L., Powell, J.S., Brown, C.M., Grund, A., Genilloud, O., Salazar, O., Thompson, D., Singh, S.B. J. Antibiot. (2008) [Pubmed]
  5. Biodiversity, chemical diversity and drug discovery. Singh, S.B., Pelaez, F. Prog. Drug. Res (2008) [Pubmed]
  6. Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing. Singh, S.B., Phillips, J.W., Wang, J. Curr. Opin. Drug. Discov. Devel (2007) [Pubmed]
  7. Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa. Singh, S.B., Occi, J., Jayasuriya, H., Herath, K., Motyl, M., Dorso, K., Gill, C., Hickey, E., Overbye, K.M., Barrett, J.F., Masurekar, P. J. Antibiot. (2007) [Pubmed]
  8. Discovery of lucensimycins A and B from Streptomyces lucensis MA7349 using an antisense strategy. Singh, S.B., Zink, D.L., Huber, J., Genilloud, O., Salazar, O., Diez, M.T., Basilio, A., Vicente, F., Byrne, K.M. Org. Lett. (2006) [Pubmed]
  9. Empirical antibacterial drug discovery--foundation in natural products. Singh, S.B., Barrett, J.F. Biochem. Pharmacol. (2006) [Pubmed]
  10. Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy. Singh, S.B., Jayasuriya, H., Ondeyka, J.G., Herath, K.B., Zhang, C., Zink, D.L., Tsou, N.N., Ball, R.G., Basilio, A., Genilloud, O., Diez, M.T., Vicente, F., Pelaez, F., Young, K., Wang, J. J. Am. Chem. Soc. (2006) [Pubmed]
  11. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Singh, S.B., Ondeyka, J.G., Liu, W., Chen, S., Chen, T.S., Li, X., Bouffard, A., Dropinski, J., Jones, A.B., McCormick, S., Hayes, N., Wang, J., Sharma, N., Macnaul, K., Hernandez, M., Chao, Y.S., Baffic, J., Lam, M.H., Burton, C., Sparrow, C.P., Menke, J.G. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  12. New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity. Singh, S.B., Kelly, R., Guan, Z., Polishook, J.D., Domrowski, A.W., Collado, J., Gonzalez, A., Pelaez, F., Register, E., Kelly, T.M., Bonfiglio, C., Williamson, J.M. Nat. Prod. Res. (2005) [Pubmed]
  13. Citrafungins A and B, two new fungal metabolite inhibitors of GGTase I with antifungal activity. Singh, S.B., Zink, D.L., Doss, G.A., Polishook, J.D., Ruby, C., Register, E., Kelly, T.M., Bonfiglio, C., Williamson, J.M., Kelly, R. Org. Lett. (2004) [Pubmed]
  14. Nodulisporic acids D-F: structure, biological activities, and biogenetic relationships. Singh, S.B., Ondeyka, J.G., Jayasuriya, H., Zink, D.L., Ha, S.N., Dahl-Roshak, A., Greene, J., Kim, J.A., Smith, M.M., Shoop, W., Tkacz, J.S. J. Nat. Prod. (2004) [Pubmed]
  15. Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Singh, S.B., Ondeyka, J.G., Tsipouras, N., Ruby, C., Sardana, V., Schulman, M., Sanchez, M., Pelaez, F., Stahlhut, M.W., Munshi, S., Olsen, D.B., Lingham, R.B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  16. Integracides: tetracyclic triterpenoid inhibitors of HIV-1 integrase produced by Fusarium sp. Singh, S.B., Zink, D.L., Dombrowski, A.W., Polishook, J.D., Ondeyka, J.G., Hirshfield, J., Felock, P., Hazuda, D.J. Bioorg. Med. Chem. (2003) [Pubmed]
  17. Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase. Singh, S.B., Zink, D.L., Bills, G.F., Teran, A., Silverman, K.C., Lingham, R.B., Felock, P., Hazuda, D.J. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  18. Chemistry and structure-activity relationship of HIV-1 integrase inhibitor integracide B and related natural products. Singh, S.B., Ondeyka, J.G., Schleif, W.A., Felock, P., Hazuda, D.J. J. Nat. Prod. (2003) [Pubmed]
  19. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. Singh, S.B., Jayasuriya, H., Dewey, R., Polishook, J.D., Dombrowski, A.W., Zink, D.L., Guan, Z., Collado, J., Platas, G., Pelaez, F., Felock, P.J., Hazuda, D.J. J. Ind. Microbiol. Biotechnol. (2003) [Pubmed]
  20. Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities. Singh, S.B., Zink, D.L., Liesch, J.M., Mosley, R.T., Dombrowski, A.W., Bills, G.F., Darkin-Rattray, S.J., Schmatz, D.M., Goetz, M.A. J. Org. Chem. (2002) [Pubmed]
  21. Structure, stereochemistry, and biological activity of integramycin, a novel hexacyclic natural product produced by Actinoplanes sp. that inhibits HIV-1 integrase. Singh, S.B., Zink, D.L., Heimbach, B., Genilloud, O., Teran, A., Silverman, K.C., Lingham, R.B., Felock, P., Hazuda, D.J. Org. Lett. (2002) [Pubmed]
  22. Current progress on farnesyl protein transferase inhibitors. Singh, S.B., Lingham, R.B. Curr. Opin. Drug. Discov. Devel (2002) [Pubmed]
  23. Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase. Singh, S.B., Herath, K., Guan, Z., Zink, D.L., Dombrowski, A.W., Polishook, J.D., Silverman, K.C., Lingham, R.B., Felock, P.J., Hazuda, D.J. Org. Lett. (2002) [Pubmed]
  24. Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3. Singh, S.B., Zink, D.L., Dombrowski, A.W., Dezeny, G., Bills, G.F., Felix, J.P., Slaughter, R.S., Goetz, M.A. Org. Lett. (2001) [Pubmed]
  25. The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I. Singh, S.B., Jayasuriya, H., Salituro, G.M., Zink, D.L., Shafiee, A., Heimbuch, B., Silverman, K.C., Lingham, R.B., Genilloud, O., Teran, A., Vilella, D., Felock, P., Hazuda, D. J. Nat. Prod. (2001) [Pubmed]
  26. Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. Singh, S.B., Tomassini, J.E. J. Org. Chem. (2001) [Pubmed]
  27. Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions. Singh, S.B., Zink, D.L., Liesch, J.M., Dombrowski, A.W., Darkin-Rattray, S.J., Schmatz, D.M., Goetz, M.A. Org. Lett. (2001) [Pubmed]
  28. Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues. Singh, S.B., Graham, P.L., Reamer, R.A., Cordingley, M.G. Bioorg. Med. Chem. Lett. (2001) [Pubmed]
  29. Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity. Singh, S.B., Felock, P., Hazuda, D.J. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
  30. Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues. Singh, S.B., Jayasuriya, H., Silverman, K.C., Bonfiglio, C.A., Williamson, J.M., Lingham, R.B. Bioorg. Med. Chem. (2000) [Pubmed]
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