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Tsutomu Shimada

Osaka Prefectural Institute of Public Health

3-69 Nakamichi 1-chome

Higashinari-ku

Osaka 537

Japan

[email]@*.*.osaka.jp

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Affiliations

Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka 537, Japan. 1999 - 2003
Osaka Prefectural Institute of Public Health, Japan. 1997 - 2001
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA. 1998

References

Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. Shimada, T., Sugie, A., Shindo, M., Nakajima, T., Azuma, E., Hashimoto, M., Inoue, K. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Shimada, T., Inoue, K., Suzuki, Y., Kawai, T., Azuma, E., Nakajima, T., Shindo, M., Kurose, K., Sugie, A., Yamagishi, Y., Fujii-Kuriyama, Y., Hashimoto, M. Carcinogenesis (2002) [Pubmed]
Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. Shimada, T., Tsumura, F., Yamazaki, H., Guengerich, F.P., Inoue, K. Pharmacogenetics (2001) [Pubmed]
Specificity of 17beta-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432. Shimada, T., Watanabe, J., Inoue, K., Guengerich, F.P., Gillam, E.M. Xenobiotica (2001) [Pubmed]
Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Shimada, T., Oda, Y., Gillam, E.M., Guengerich, F.P., Inoue, K. Drug Metab. Dispos. (2001) [Pubmed]
Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. Shimada, T., Tsumura, F., Gillam, E.M., Guengerich, F.P., Inoue, K. Protein Expr. Purif. (2000) [Pubmed]
Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Shimada, T., Gillam, E.M., Oda, Y., Tsumura, F., Sutter, T.R., Guengerich, F.P., Inoue, K. Chem. Res. Toxicol. (1999) [Pubmed]
Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Shimada, T., Tsumura, F., Yamazaki, H. Drug Metab. Dispos. (1999) [Pubmed]
Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Shimada, T., Yamazaki, H., Foroozesh, M., Hopkins, N.E., Alworth, W.L., Guengerich, F.P. Chem. Res. Toxicol. (1998) [Pubmed]
Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. Shimada, T., El-Bayoumy, K., Upadhyaya, P., Sutter, T.R., Guengerich, F.P., Yamazaki, H. Cancer Res. (1997) [Pubmed]