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Stefan A. Laufer

Pharmazeutisches Institut

Eberhard Karls Universität Tübingen




Name/email consistency: high



  • Pharmazeutisches Institut, Eberhard Karls Universität Tübingen, Tübingen, Germany. 2010
  • Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tübingen, Auf der Morgenstelle 8, Germany. 2002 - 2010
  • Institute of Pharmacy, University of Tuebingen, Auf der Morgenstelle 8b, DE-72076 Tuebingen, Germany. 2003 - 2004
  • Institute of Pharmacy, University of Tuebingen, Germany. 2003


  1. Different methods for testing potential cyclooxygenase-1 and cyclooxygenase-2 inhibitors. Laufer, S., Luik, S. Methods Mol. Biol. (2010) [Pubmed]
  2. Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors. Laufer, S., Hauser, D., Stegmiller, T., Bracht, C., Ruff, K., Schattel, V., Albrecht, W., Koch, P. Bioorg. Med. Chem. Lett. (2010) [Pubmed]
  3. Isoxazolone based inhibitors of p38 MAP kinases. Laufer, S.A., Margutti, S. J. Med. Chem. (2008) [Pubmed]
  4. Towards the improvement of the synthesis of novel 4(5)-aryl-5(4)-heteroaryl-2-thio-substituted imidazoles and their p38 MAP kinase inhibitory activity. Laufer, S., Koch, P. Org. Biomol. Chem. (2008) [Pubmed]
  5. Human whole blood assay for rapid and routine testing of non-steroidal anti-inflammatory drugs (NSAIDs) on cyclo-oxygenase-2 activity. Laufer, S., Greim, C., Luik, S., Ayoub, S.S., Dehner, F. Inflammopharmacology (2008) [Pubmed]
  6. Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. Laufer, S.A., Hauser, D.R., Domeyer, D.M., Kinkel, K., Liedtke, A.J. J. Med. Chem. (2008) [Pubmed]
  7. Substituted isoxazoles as potent inhibitors of p38 MAP kinase. Laufer, S.A., Margutti, S., Fritz, M.D. ChemMedChem (2006) [Pubmed]
  8. Development of a microsphere-based p38alpha kinase no-wash assay. Laufer, S., Linsenmaier, S. J. Biomol. Screen (2006) [Pubmed]
  9. Design, synthesis, and biological evaluation of phenylamino-substituted 6,11-dihydro-dibenzo[b,e]oxepin-11-ones and dibenzo[a,d]cycloheptan-5-ones: novel p38 MAP kinase inhibitors. Laufer, S.A., Ahrens, G.M., Karcher, S.C., Hering, J.S., Niess, R. J. Med. Chem. (2006) [Pubmed]
  10. Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. Laufer, S.A., Domeyer, D.M., Scior, T.R., Albrecht, W., Hauser, D.R. J. Med. Chem. (2005) [Pubmed]
  11. An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays. Laufer, S., Thuma, S., Peifer, C., Greim, C., Herweh, Y., Albrecht, A., Dehner, F. Anal. Biochem. (2005) [Pubmed]
  12. Osteoarthritis therapy--are there still unmet needs?. Laufer, S. Rheumatology. (Oxford) (2004) [Pubmed]
  13. Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position. Laufer, S.A., Zimmermann, W., Ruff, K.J. J. Med. Chem. (2004) [Pubmed]
  14. International Conference on Inflammopharmacology -- VIII Side-Effects of Anti-inflammatory Drugs Symposium. Laufer, S. Expert. Opin. Investig. Drugs (2003) [Pubmed]
  15. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. Laufer, S.A., Wagner, G.K., Kotschenreuther, D.A., Albrecht, W. J. Med. Chem. (2003) [Pubmed]
  16. Role of eicosanoids in structural degradation in osteoarthritis. Laufer, S. Curr. Opin. Rheumatol (2003) [Pubmed]
  17. From imidazoles to pyrimidines: new inhibitors of cytokine release. Laufer, S.A., Wagner, G.K. J. Med. Chem. (2002) [Pubmed]
  18. Ones, thiones, and N-oxides: an exercise in imidazole chemistry. Laufer, S., Wagner, G., Kotschenreuther, D. Angew. Chem. Int. Ed. Engl. (2002) [Pubmed]
  19. Imidazole inhibitors of cytokine release: probing substituents in the 2 position. Laufer, S.A., Striegel, H.G., Wagner, G.K. J. Med. Chem. (2002) [Pubmed]
  20. An in-vitro screening assay for the detection of inhibitors of proinflammatory cytokine synthesis: a useful tool for the development of new antiarthritic and disease modifying drugs. Laufer, S., Greim, C., Bertsche, T. Osteoarthr. Cartil. (2002) [Pubmed]
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