Stephen Hanessian
Department of Chemistry
Université de Montréal
C.P. 6128
Succursale Centre-Ville Montréal
Canada
Name/email consistency: high
- The enterprise of synthesis: from concept to practice. Hanessian, S. J. Org. Chem. (2012)
- A new approach to the synthesis of peptidomimetic renin inhibitors: palladium-catalyzed asymmetric allylation of acyclic alkyl aryl ketones. Hanessian, S., Chénard, E. Org. Lett. (2012)
- Structure-Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle γ. Hanessian, S., Schroeder, B.R., Giacometti, R.D., Merner, B.L., Ostergaard, M., Swayze, E.E., Seth, P.P. Angew. Chem. Int. Ed. Engl. (2012)
- Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation. Hanessian, S., Maianti, J.P., Matias, R.D., Feeney, L.A., Armstrong, E.S. Org. Lett. (2011)
- Total synthesis of pactamycin. Hanessian, S., Vakiti, R.R., Dorich, S., Banerjee, S., Lecomte, F., DelValle, J.R., Zhang, J., Deschênes-Simard, B. Angew. Chem. Int. Ed. Engl. (2011)
- Total synthesis of (+)-ent-cyclizidine: absolute configurational confirmation of antibiotic M146791. Hanessian, S., Soma, U., Dorich, S., Deschênes-Simard, B. Org. Lett. (2011)
- Applications of organocatalytic asymmetric synthesis to drug prototypes--dual action and selective inhibitors of n-nitric oxide synthase with activity against the 5-HT1D/1B subreceptors. Hanessian, S., Stoffman, E., Mi, X., Renton, P. Org. Lett. (2011)
- Total synthesis of "aliskiren": the first Renin inhibitor in clinical practice for hypertension. Hanessian, S., Guesné, S., Chénard, E. Org. Lett. (2010)
- Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa. Hanessian, S., Larsson, A., Fex, T., Knecht, W., Blomberg, N. Bioorg. Med. Chem. Lett. (2010)
- Total synthesis of jerangolid A. Hanessian, S., Focken, T., Oza, R. Org. Lett. (2010)
- Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin. Hanessian, S., Maianti, J.P. Chem. Commun. (Camb.) (2010)
- Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria. Hanessian, S., Pachamuthu, K., Szychowski, J., Giguère, A., Swayze, E.E., Migawa, M.T., François, B., Kondo, J., Westhof, E. Bioorg. Med. Chem. Lett. (2010)
- Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit. Hanessian, S., Focken, T., Mi, X., Oza, R., Chen, B., Ritson, D., Beaudegnies, R. J. Org. Chem. (2010)
- Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. Hanessian, S., Shao, Z., Betschart, C., Rondeau, J.M., Neumann, U., Tintelnot-Blomley, M. Bioorg. Med. Chem. Lett. (2010)
- Total synthesis and structural revision of the presumed aeruginosins 205A and B. Hanessian, S., Wang, X., Ersmark, K., Del Valle, J.R., Klegraf, E. Org. Lett. (2009)
- Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans. Hanessian, S., Szychowski, J., Maianti, J.P. Org. Lett. (2009)
- From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Hanessian, S., Therrien, E., Zhang, J., Otterlo, W., Xue, Y., Gustafsson, D., Nilsson, I., Fjellström, O. Bioorg. Med. Chem. Lett. (2009)
- Total synthesis of oidiodendrolides and related norditerpene dilactones from a common precursor: metabolites CJ-14,445, LL-Z1271gamma, oidiolactones A, B, C, and D, and nagilactone F. Hanessian, S., Boyer, N., Reddy, G.J., Deschênes-Simard, B. Org. Lett. (2009)
- Targeting ACE and ECE with dual acting inhibitors. Hanessian, S., Guesné, S., Riber, L., Marin, J., Benoist, A., Mennecier, P., Rupin, A., Verbeuren, T.J., De Nanteuil, G. Bioorg. Med. Chem. Lett. (2008)
- The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids. Hanessian, S., Auzzas, L. Acc. Chem. Res. (2008)
- Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs. Hanessian, S., Simard, D., Bayrakdarian, M., Therrien, E., Nilsson, I., Fjellström, O. Bioorg. Med. Chem. Lett. (2008)
- Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs. Hanessian, S., Grzyb, J.A., Cengelli, F., Juillerat-Jeanneret, L. Bioorg. Med. Chem. (2008)
- Proximity-assisted cycloaddition reactions--facile Lewis acid-mediated synthesis of diversely functionalized bicyclic tetrazoles. Hanessian, S., Simard, D., Deschênes-Simard, B., Chenel, C., Haak, E. Org. Lett. (2008)
- Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: design, synthesis, and X-ray crystal superstructure. Hanessian, S., Vinci, V., Fettis, K., Maris, T., Viet, M.T. J. Org. Chem. (2008)
- 6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase. Hanessian, S., Szychowski, J., Campos-Reales Pineda, N.B., Furtos, A., Keillor, J.W. Bioorg. Med. Chem. Lett. (2007)
- Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin. Hanessian, S., Szychowski, J., Adhikari, S.S., Vasquez, G., Kandasamy, P., Swayze, E.E., Migawa, M.T., Ranken, R., François, B., Wirmer-Bartoschek, J., Kondo, J., Westhof, E. J. Med. Chem. (2007)
- Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Hanessian, S., Auzzas, L., Giannini, G., Marzi, M., Cabri, W., Barbarino, M., Vesci, L., Pisano, C. Bioorg. Med. Chem. Lett. (2007)
- Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. Hanessian, S., Charron, G., Billich, A., Guerini, D. Bioorg. Med. Chem. Lett. (2007)
- Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin. Hanessian, S., Ersmark, K., Wang, X., Del Valle, J.R., Blomberg, N., Xue, Y., Fjellström, O. Bioorg. Med. Chem. Lett. (2007)
- Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure. Hanessian, S., Therrien, E., van Otterlo, W.A., Bayrakdarian, M., Nilsson, I., Fjellström, O., Xue, Y. Bioorg. Med. Chem. Lett. (2006)
- Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme. Hanessian, S., Gauchet, C., Charron, G., Marin, J., Nakache, P. J. Org. Chem. (2006)
- Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). Hanessian, S., Yang, G., Rondeau, J.M., Neumann, U., Betschart, C., Tintelnot-Blomley, M. J. Med. Chem. (2006)
- Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA. Hanessian, S., Vinci, V., Auzzas, L., Marzi, M., Giannini, G. Bioorg. Med. Chem. Lett. (2006)
- Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A. Hanessian, S., Mainetti, E., Lecomte, F. Org. Lett. (2006)
- Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design. Hanessian, S., Chahal, N., Giroux, S. J. Org. Chem. (2006)
- Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline. Hanessian, S., Shao, Z., Warrier, J.S. Org. Lett. (2006)
- Structure-based organic synthesis of drug prototypes: a personal odyssey. Hanessian, S. Chemmedchem (2006)
- Total synthesis and stereochemical confirmation of manassantin A, B, and B1. Hanessian, S., Reddy, G.J., Chahal, N. Org. Lett. (2006)
- Structure-based organic synthesis of a tricyclic N-malayamycin analogue. Hanessian, S., Ritson, D.J. J. Org. Chem. (2006)
- Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric implications of nucleophilic alkene, alkyne, and allene tethers. Hanessian, S., Tremblay, M., Marzi, M., Del Valle, J.R. J. Org. Chem. (2005)
- 3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin. Hanessian, S., Kothakonda, K.K. Bioorg. Med. Chem. (2005)
- Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. Hanessian, S., Yun, H., Hou, Y., Yang, G., Bayrakdarian, M., Therrien, E., Moitessier, N., Roggo, S., Veenstra, S., Tintelnot-Blomley, M., Rondeau, J.M., Ostermeier, C., Strauss, A., Ramage, P., Paganetti, P., Neumann, U., Betschart, C. J. Med. Chem. (2005)
- Total synthesis of N-malayamycin A and related bicyclic purine and pyrimidine nucleosides. Hanessian, S., Huang, G., Chenel, C., Machaalani, R., Loiseleur, O. J. Org. Chem. (2005)
- Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids. Hanessian, S., Hou, Y., Bayrakdarian, M., Tintelnot-Blomley, M. J. Org. Chem. (2005)
- Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids. Hanessian, S., Yun, H., Hou, Y., Tintelnot-Blomley, M. J. Org. Chem. (2005)
- Total synthesis and structural confirmation of (+)-longicin. Hanessian, S., Giroux, S., Buffat, M. Org. Lett. (2005)
- Probing the "additive effect" in the proline and proline hydroxamic acid catalyzed asymmetric addition of nitroalkanes to cyclic enones. Hanessian, S., Govindan, S., Warrier, J.S. Chirality (2005)
- Natural products as scaffolds for chemical diversification: solution-phase parallel synthesis of a series of naringin analogues. Hanessian, S., Kothakonda, K.K. J. Comb. Chem (2005)
- Man, machine and visual imagery in strategic synthesis planning: computer-perceived precursors for drug candidates. Hanessian, S. Curr. Opin. Drug. Discov. Devel (2005)
- The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin. Hanessian, S., Tremblay, M., Petersen, J.F. J. Am. Chem. Soc. (2004)
- Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates. Hanessian, S., Mascitti, V., Giroux, S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Synthesis of 3 10-helix-inducing constrained analogues of L-proline. Hanessian, S., Papeo, G., Fettis, K., Therrien, E., Viet, M.T. J. Org. Chem. (2004)
- Sulfonamide-based acyclic and conformationally constrained MMP inhibitors: from computer-assisted design to nanomolar compounds. Hanessian, S., Moitessier, N. Curr. Top. Med. Chem (2004)
- Tandem functionalization of nonactivated alkenes and alkynes in intramolecular N-acyloxyiminium ion carbocyclization. Synthesis of 6-substituted hydroindole 2-carboxylic acids. Hanessian, S., Tremblay, M. Org. Lett. (2004)
- The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. Hanessian, S., Parthasarathy, S., Mauduit, M., Payza, K. J. Med. Chem. (2003)
- Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells. Hanessian, S., Zhan, L., Bovey, R., Saavedra, O.M., Juillerat-Jeanneret, L. J. Med. Chem. (2003)
- Synthesis of functionally diverse and conformationally constrained polycyclic analogues of proline and prolinol. Hanessian, S., Papeo, G., Angiolini, M., Fettis, K., Beretta, M., Munro, A. J. Org. Chem. (2003)
- Synthesis of diversely functionalized indolizidinones and related bicyclic lactams using intramolecular Grubbs olefin metathesis and Dieckmann condensation. Hanessian, S., Sailes, H., Munro, A., Therrien, E. J. Org. Chem. (2003)
- Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate. Hanessian, S., Yang, Y., Giroux, S., Mascitti, V., Ma, J., Raeppel, F. J. Am. Chem. Soc. (2003)
- Total synthesis and structural confirmation of malayamycin A: a novel bicyclic C-nucleoside from Streptomyces malaysiensis. Hanessian, S., Marcotte, S., Machaalani, R., Huang, G. Org. Lett. (2003)
- Conformationally stable and constrained macrocarbocyclic pseudopeptide mimics of beta-hairpin structures. Hanessian, S., Angiolini, M. Chemistry (2002)
- Total synthesis of A-315675: a potent inhibitor of influenza neuraminidase. Hanessian, S., Bayrakdarian, M., Luo, X. J. Am. Chem. Soc. (2002)
- Synthesis of a potent antagonist of E-selectin. Hanessian, S., Mascitti, V., Rogel, O. J. Org. Chem. (2002)
- Design and synthesis of a novel class of constrained tricyclic pyrrolizidinone carboxylic acids as carbapenem mimics. Hanessian, S., Buckle, R., Bayrakdarian, M. J. Org. Chem. (2002)
- The power of visual imagery in synthesis planning. Stereocontrolled approaches to CGP-60536B, a potent renin inhibitor. Hanessian, S., Claridge, S., Johnstone, S. J. Org. Chem. (2002)
- Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones. Hanessian, S., Therrien, E., Granberg, K., Nilsson, I. Bioorg. Med. Chem. Lett. (2002)
- Total synthesis and structural confirmation of the marine natural product Dysinosin A: a novel inhibitor of thrombin and Factor VIIa. Hanessian, S., Margarita, R., Hall, A., Johnstone, S., Tremblay, M., Parlanti, L. J. Am. Chem. Soc. (2002)
- Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm. Hanessian, S., Wang, J., Montgomery, D., Stoll, V., Stewart, K.D., Kati, W., Maring, C., Kempf, D., Hutchins, C., Laver, W.G. Bioorg. Med. Chem. Lett. (2002)
- A comparative docking study and the design of potentially selective MMP inhibitors. Hanessian, S., Moitessier, N., Therrien, E. J. Comput. Aided Mol. Des. (2001)
