Theodore A. Slotkin
Department of Pharmacology & Cancer Biology
Duke University Medical Center
Durham
NC, USA. Electronic address:
Name/email consistency: high
- Chlorpyrifos developmental neurotoxicity: Interaction with glucocorticoids in PC12 cells. Slotkin, T.A., Card, J., Seidler, F.J. Neurotoxicol. Teratol (2012)
- Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity? Slotkin, T.A. Reprod. Toxicol. (2011)
- Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model. Slotkin, T.A., Seidler, F.J., Fumagalli, F. Neurotoxicol. Teratol (2010)
- Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. Slotkin, T.A., Lobner, D., Seidler, F.J. Brain Res. Bull. (2010)
- Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. Slotkin, T.A., Seidler, F.J. Neurotoxicol. Teratol (2010)
- Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery. Slotkin, T.A., Ryde, I.T., Seidler, F.J. Brain Res. Bull. (2010)
- Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Slotkin, T.A., Seidler, F.J. Brain Res. (2010)
- Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood. Slotkin, T.A., Seidler, F.J. Brain Res. Bull. (2010)
- Benzo[a]pyrene impairs neurodifferentiation in PC12 cells. Slotkin, T.A., Seidler, F.J. Brain Res. Bull. (2009)
- Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. Slotkin, T.A., Lassiter, T.L., Ryde, I.T., Wrench, N., Levin, E.D., Seidler, F.J. Environ. Health Perspect. (2009)
- Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. Slotkin, T.A., Seidler, F.J. Environ. Health Perspect. (2009)
- Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells. Slotkin, T.A., Seidler, F.J., Wu, C., MacKillop, E.A., Linden, K.G. Environ. Health Perspect. (2009)
- Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. Slotkin, T.A., Wrench, N., Ryde, I.T., Lassiter, T.L., Levin, E.D., Seidler, F.J. Neurotoxicol. Teratol (2009)
- Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Slotkin, T.A., Seidler, F.J. Brain Res. (2009)
- Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. Slotkin, T.A., Levin, E.D., Seidler, F.J. Neurotoxicol. Teratol (2009)
- Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. Slotkin, T., Seidler, F. Brain Res. Bull. (2009)
- Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood. Slotkin, T.A., Seidler, F.J. Dev. Neurosci. (2009)
- Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions. Slotkin, T.A., Ryde, I.T., Wrench, N., Card, J.A., Seidler, F.J. Neurotoxicol. Teratol (2009)
- Development of glucocorticoid receptor regulation in the rat forebrain: implications for adverse effects of glucocorticoids in preterm infants. Slotkin, T.A., Seidler, F.J., Wood, C.R., Lau, C. Brain Res. Bull. (2008)
- Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects. Slotkin, T.A., Ryde, I.T., Mackillop, E.A., Bodwell, B.E., Seidler, F.J. Brain Res. Bull. (2008)
- Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model. Slotkin, T.A., Seidler, F.J., Ryde, I.T., Yanai, J. Neurotoxicol. Teratol (2008)
- Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Slotkin, T.A., Bodwell, B.E., Levin, E.D., Seidler, F.J. Environ. Health Perspect. (2008)
- Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. Slotkin, T.A., MacKillop, E.A., Melnick, R.L., Thayer, K.A., Seidler, F.J. Environ. Health Perspect. (2008)
- If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents? Slotkin, T.A. Neurotoxicol. Teratol (2008)
- Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. Slotkin, T.A., Ryde, I.T., Levin, E.D., Seidler, F.J. Brain Res. Bull. (2008)
- Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Slotkin, T.A., Seidler, F.J. Toxicol. Appl. Pharmacol. (2008)
- Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Slotkin, T.A., Seidler, F.J., Fumagalli, F. Brain Res. Bull. (2008)
- Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. Slotkin, T.A., Bodwell, B.E., Ryde, I.T., Levin, E.D., Seidler, F.J. Environ. Health Perspect. (2008)
- Adolescent nicotine treatment changes the response of acetylcholine systems to subsequent nicotine administration in adulthood. Slotkin, T.A., Bodwell, B.E., Ryde, I.T., Seidler, F.J. Brain Res. Bull. (2008)
- Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Slotkin, T.A., MacKillop, E.A., Ryde, I.T., Seidler, F.J. Environ. Health Perspect. (2007)
- Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. Slotkin, T.A., MacKillop, E.A., Rudder, C.L., Ryde, I.T., Tate, C.A., Seidler, F.J. Neuropsychopharmacology (2007)
- Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Slotkin, T.A., Seidler, F.J. Reprod. Toxicol. (2007)
- Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Slotkin, T.A., Seidler, F.J., Fumagalli, F. Environ. Health Perspect. (2007)
- A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration. Slotkin, T.A., Seidler, F.J. Neurotoxicol. Teratol (2007)
- Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions. Slotkin, T.A., Ryde, I.T., Seidler, F.J. Brain Res. Bull. (2007)
- Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Slotkin, T.A., Seidler, F.J. Brain Res. Bull. (2007)
- Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Slotkin, T.A., Seidler, F.J. Brain Res. Bull. (2007)
- Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood. Slotkin, T.A., Ryde, I.T., Tate, C.A., Seidler, F.J. Brain Res. Bull. (2007)
- Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. Slotkin, T.A., MacKillop, E.A., Ryde, I.T., Tate, C.A., Seidler, F.J. Environ. Health Perspect. (2007)
- Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems. Slotkin, T.A., Kreider, M.L., Tate, C.A., Seidler, F.J. Neuropsychopharmacology (2006)
- Cholinergic receptor subtypes in the olfactory bulbectomy model of depression. Slotkin, T.A., Seidler, F.J. Brain Res. Bull. (2006)
- Perinatal environmental tobacco smoke exposure in rhesus monkeys: critical periods and regional selectivity for effects on brain cell development and lipid peroxidation. Slotkin, T.A., Pinkerton, K.E., Seidler, F.J. Environ. Health Perspect. (2006)
- Anomalous regulation of beta-adrenoceptor signaling in brain regions of the newborn rat. Slotkin, T.A., Seidler, F.J. Brain Res. (2006)
- Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Slotkin, T.A., Levin, E.D., Seidler, F.J. Environ. Health Perspect. (2006)
- Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke. Slotkin, T.A., Pinkerton, K.E., Tate, C.A., Seidler, F.J. Brain Res. (2006)
- Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. Slotkin, T.A., Seidler, F.J., Qiao, D., Aldridge, J.E., Tate, C.A., Cousins, M.M., Proskocil, B.J., Sekhon, H.S., Clark, J.A., Lupo, S.L., Spindel, E.R. Neuropsychopharmacology (2005)
- Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. Slotkin, T.A., Cousins, M.M., Tate, C.A., Seidler, F.J. Neuropsychopharmacology (2005)
- The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Slotkin, T.A., Seidler, F.J. Brain Res. Dev. Brain Res. (2005)
- Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Slotkin, T.A., Brown, K.K., Seidler, F.J. Environ. Health Perspect. (2005)
- Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Slotkin, T.A., Tate, C.A., Cousins, M.M., Seidler, F.J. Brain Res. Dev. Brain Res. (2005)
- Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. Slotkin, T.A. Neurotoxicology (2004)
- Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Slotkin, T.A. Toxicol. Appl. Pharmacol. (2004)
- Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. Slotkin, T.A., Southard, M.C., Adam, S.J., Cousins, M.M., Seidler, F.J. Brain Res. Bull. (2004)
- Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors. Slotkin, T.A., Cousins, M.M., Seidler, F.J. Brain Res. (2004)
- Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs. Slotkin, T.A., Auman, J.T., Seidler, F.J. J. Pharmacol. Exp. Ther. (2003)
- Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. Slotkin, T.A., Freibaum, B.D., Tate, C.A., Thillai, I., Ferguson, S.A., Cada, A.M., Seidler, F.J. Brain Res. (2003)
- Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity. Slotkin, T.A., Seidler, F.J., Yanai, J. Brain Res. (2003)
- Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Slotkin, T.A., Tate, C.A., Cousins, M.M., Seidler, F.J. Brain Res. Dev. Brain Res. (2002)
- Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. Slotkin, T.A., Pinkerton, K.E., Auman, J.T., Qiao, D., Seidler, F.J. Brain Res. Dev. Brain Res. (2002)
- Nicotine and the adolescent brain: insights from an animal model. Slotkin, T.A. Neurotoxicol. Teratol (2002)
- Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats. Slotkin, T.A., Pinkerton, K.E., Garofolo, M.C., Auman, J.T., McCook, E.C., Seidler, F.J. Brain Res. (2001)
- Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Slotkin, T.A., Cousins, M.M., Tate, C.A., Seidler, F.J. Brain Res. (2001)
- Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline. Slotkin, T.A., Tate, C.A., Cousins, M.M., Seidler, F.J. Brain Res. Dev. Brain Res. (2001)
- Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism. Slotkin, T.A., Seidler, F.J., Yanai, J. Brain Res. Dev. Brain Res. (2001)
- Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. Slotkin, T.A., Zhang, J., Dancel, R., Garcia, S.J., Willis, C., Seidler, F.J. Breast Cancer Res. Treat. (2000)
- Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. Slotkin, T.A., Seidler, F.J., Ali, S.F. Brain Res. (2000)
- Regional differences in brain monoamine oxidase subtypes in an animal model of geriatric depression: effects of olfactory bulbectomy in young versus aged rats. Slotkin, T.A., Seidler, F.J., Ritchie, J.C. Brain Res. (2000)
- Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung. Slotkin, T.A., Pinkerton, K.E., Seidler, F.J. Brain Res. Dev. Brain Res. (2000)
- Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth. Slotkin, T.A., Ferguson, S.A., Cada, A.M., McCook, E.C., Seidler, F.J. Brain Res. (2000)
- Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells. Slotkin, T.A., Seidler, F.J. Breast Cancer Res. Treat. (2000)
- Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality. Slotkin, T.A., Epps, T.A., Stenger, M.L., Sawyer, K.J., Seidler, F.J. Brain Res. Dev. Brain Res. (1999)
- Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. Slotkin, T.A., Miller, D.B., Fumagalli, F., McCook, E.C., Zhang, J., Bissette, G., Seidler, F.J. J. Pharmacol. Exp. Ther. (1999)
- Mary Bernheim and the discovery of monoamine oxidase. Slotkin, T.A. Brain Res. Bull. (1999)
- Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats. Slotkin, T.A., Zhang, J., McCook, E.C., Seidler, F.J. Brain Res. (1998)
- Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. Slotkin, T.A., Zhang, J., McCook, E.C., Seidler, F.J. Brain Res. Dev. Brain Res. (1998)
- Effects of aging and glucocorticoid treatment on monoamine oxidase subtypes in rat cerebral cortex: therapeutic implications. Slotkin, T.A., Seidler, F.J., Ritchie, J.C. Brain Res. Bull. (1998)
