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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Johannes D. Veldhuis

Endocrine Research Unit

Mayo School of Graduate Medical Education

National Institutes of Health Center for Translational Science Activities

Mayo Clinic

USA

[email]@mayo.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Endocrine Research Unit, Mayo School of Graduate Medical Education, National Institutes of Health Center for Translational Science Activities, Mayo Clinic, USA. 2012
  • Department of Medicine, Endocrine Research Unit and Biophysics Section, Mayo School of Graduate Medical Education, Clinical Translational Science Center, USA. Electronic address:. 2005 - 2012
  • Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. 2007 - 2012
  • Mayo Clinic and Graduate School of Medicine and Center for Translational Science Activities - Endocrine Res Unit, Rochester, Minnesota 55905. 2011
  • Departments of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, Rochester, USA. 2003 - 2009
  • Departments of Internal Medicine, Endocrine Research Unit, Clinical Translational Research Unit, Mayo Medical and Graduate Schools of Medicine, USA. 2009
  • Division of Endocrinology and Metabolism, Dept. of Internal Medicine, Mayo Medical School and Graduate School of Medicine, General Clinical Research Center, USA. 2003 - 2006
  • Department of Internal Medicine, Division of Endocrinology, General Clinical Research Center, Center for Biochemical Technology, USA. 2002 - 2005
  • Mayo Clinic and Graduate School of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Rochester, USA. 2003
  • University of Virginia School of Medicine, Charlottesville, USA. 2003

References

  1. Sex steroids, GHRH, somatostatin, IGF-I, and IGFBP-1 modulate ghrelin's dose-dependent drive of pulsatile GH secretion in healthy older men. Veldhuis, J.D., Norman, C., Miles, J.M., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2012) [Pubmed]
  2. Dynamic testosterone responses to near-physiological LH pulses are determined by the time pattern of prior intravenous LH infusion. Veldhuis, J.D., Liu, P.Y., Takahashi, P.Y., Keenan, D.M. Am. J. Physiol. Endocrinol. Metab. (2012) [Pubmed]
  3. Analysis of the impact of intravenous LH pulses versus continuous LH infusion on testosterone secretion during GnRH-receptor blockade. Veldhuis, J.D., Liu, P.Y., Takahashi, P.Y., Weist, S.M., Wigham, J.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2012) [Pubmed]
  4. Model-based evaluation of growth hormone secretion. Veldhuis, J.D., Keenan, D.M. Meth. Enzymol. (2012) [Pubmed]
  5. Logistic model of glucose-regulated C-peptide secretion: hysteresis pathway disruption in impaired fasting glycemia. Keenan, D.M., Basu, R., Liu, Y., Basu, A., Bock, G., Veldhuis, J.D. Am. J. Physiol. Endocrinol. Metab. (2012) [Pubmed]
  6. Distinct Metabolic Surrogates Predict Basal and Rebound GH Secretion after Glucose Ingestion in Men. Iranmanesh, A., Lawson, D., Veldhuis, J.D. J. Clin. Endocrinol. Metab. (2012) [Pubmed]
  7. Older men exhibit reduced efficacy of and heightened potency downregulation by intravenous pulses of recombinant human LH: a study in 92 healthy men. Veldhuis, J.D., Liu, P.Y., Keenan, D.M., Takahashi, P.Y. Am. J. Physiol. Endocrinol. Metab. (2012) [Pubmed]
  8. Glucose ingestion acutely lowers pulsatile LH and basal testosterone secretion in men. Iranmanesh, A., Lawson, D., Veldhuis, J.D. Am. J. Physiol. Endocrinol. Metab. (2012) [Pubmed]
  9. Oscillations in joint synchrony of reproductive hormones in healthy men. Wang, X., Keenan, D.M., Pincus, S.M., Liu, P.Y., Veldhuis, J.D. Am. J. Physiol. Endocrinol. Metab. (2011) [Pubmed]
  10. Noninvasive Analytical Estimation of Endogenous GnRH Drive: Analysis Using Graded Competitive GnRH-Receptor Antagonism and a Calibrating Pulse of Exogenous GnRH. Keenan, D.M., Clarke, I.J., Veldhuis, J.D. Endocrinology (2011) [Pubmed]
  11. Glucose Ingestion Selectively Amplifies ACTH and Cortisol Secretory-Burst Mass and Enhances Their Joint Synchrony in Healthy Men. Iranmanesh, A., Lawson, D., Dunn, B., Veldhuis, J.D. J. Clin. Endocrinol. Metab. (2011) [Pubmed]
  12. Tripartite Control of Dynamic ACTH-Cortisol Dose Responsiveness by Age, Body Mass Index, and Gender in 111 Healthy Adults. Veldhuis, J.D., Iranmanesh, A., Roelfsema, F., Aoun, P., Takahashi, P., Miles, J.M., Keenan, D.M. J. Clin. Endocrinol. Metab. (2011) [Pubmed]
  13. Gender, sex-steroid, and secretagogue-selective recovery from growth hormone-induced feedback in older women and men. Veldhuis, J.D., Erickson, D., Wigham, J., Weist, S., Miles, J.M., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2011) [Pubmed]
  14. Complex regulation of GH autofeedback under dual-peptide drive: studies under a pharmacological GH and sex steroid clamp. Veldhuis, J.D., Erickson, D., Miles, J.M., Bowers, C.Y. Am. J. Physiol. Endocrinol. Metab. (2011) [Pubmed]
  15. Gender, age, body mass index, and IGF-I individually and jointly determine distinct GH dynamics: analyses in one hundred healthy adults. Veldhuis, J.D., Roelfsema, F., Keenan, D.M., Pincus, S. J. Clin. Endocrinol. Metab. (2011) [Pubmed]
  16. Regulated recovery of pulsatile growth hormone secretion from negative feedback: a preclinical investigation. Veldhuis, J.D., Bowers, C.Y. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2011) [Pubmed]
  17. Age disrupts androgen receptor-modulated negative feedback in the gonadal axis in healthy men. Veldhuis, J.D., Takahashi, P.Y., Keenan, D.M., Liu, P.Y., Mielke, K.L., Weist, S.M. Am. J. Physiol. Endocrinol. Metab. (2010) [Pubmed]
  18. Kinetics of removal of intravenous testosterone pulses in normal men. Veldhuis, J.D., Keenan, D.M., Liu, P.Y., Takahashi, P.Y. Eur. J. Endocrinol. (2010) [Pubmed]
  19. Testosterone supplementation in older men restrains insulin-like growth factor's dose-dependent feedback inhibition of pulsatile growth hormone secretion. Veldhuis, J.D., Keenan, D.M., Bailey, J.N., Adeniji, A., Miles, J.M., Paulo, R., Cosma, M., Soares-Welch, C. J. Clin. Endocrinol. Metab. (2009) [Pubmed]
  20. Regulation of basal, pulsatile, and entropic (patterned) modes of GH secretion in a putatively low-somatostatin milieu in women. Veldhuis, J.D., Hudson, S.A., Bailey, J.N., Erickson, D. Am. J. Physiol. Endocrinol. Metab. (2009) [Pubmed]
  21. Relative effects of estrogen, age, and visceral fat on pulsatile growth hormone secretion in healthy women. Veldhuis, J.D., Hudson, S.B., Erickson, D., Bailey, J.N., Reynolds, G.A., Bowers, C.Y. Am. J. Physiol. Endocrinol. Metab. (2009) [Pubmed]
  22. Determinants of GH-releasing hormone and GH-releasing peptide synergy in men. Veldhuis, J.D., Bowers, C.Y. Am. J. Physiol. Endocrinol. Metab. (2009) [Pubmed]
  23. Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index. Veldhuis, J.D., Roelfsema, F., Iranmanesh, A., Carroll, B.J., Keenan, D.M., Pincus, S.M. J. Clin. Endocrinol. Metab. (2009) [Pubmed]
  24. Factors other than sex steroids modulate GHRH and GHRP-2 efficacies in men: evaluation using a GnRH agonist/testosterone clamp. Veldhuis, J.D., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2009) [Pubmed]
  25. Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp. Veldhuis, J.D., Keenan, D.M., Bailey, J.N., Adeniji, A.M., Miles, J.M., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2009) [Pubmed]
  26. Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men. Veldhuis, J.D., Mielke, K.L., Cosma, M., Soares-Welch, C., Paulo, R., Miles, J.M., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2009) [Pubmed]
  27. Preservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadism. Veldhuis, J.D., Keenan, D.M., Bailey, J.N., Miles, J.M., Bowers, C.Y. Eur. J. Endocrinol. (2009) [Pubmed]
  28. The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback. Veldhuis, J.D., Keenan, D.M., Liu, P.Y., Iranmanesh, A., Takahashi, P.Y., Nehra, A.X. Mol. Cell. Endocrinol. (2009) [Pubmed]
  29. Twenty-four hour continuous ghrelin infusion augments physiologically pulsatile, nycthemeral, and entropic (feedback-regulated) modes of growth hormone secretion. Veldhuis, J.D., Reynolds, G.A., Iranmanesh, A., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  30. Secretagogues govern GH secretory-burst waveform and mass in healthy eugonadal and short-term hypogonadal men. Veldhuis, J.D., Keenan, D.M. Eur. J. Endocrinol. (2008) [Pubmed]
  31. Aging and hormones of the hypothalamo-pituitary axis: gonadotropic axis in men and somatotropic axes in men and women. Veldhuis, J.D. Ageing Res. Rev. (2008) [Pubmed]
  32. Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I. Veldhuis, J.D., Keenan, D.M., Bailey, J.N., Adeniji, A., Miles, J.M., Paulo, R., Cosma, M., Soares-Welch, C. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  33. Motivations and methods for analyzing pulsatile hormone secretion. Veldhuis, J.D., Keenan, D.M., Pincus, S.M. Endocr. Rev. (2008) [Pubmed]
  34. Peripheral estrogen receptor-alpha selectively modulates the waveform of GH secretory bursts in healthy women. Veldhuis, J.D., Keenan, D.M., Bowers, C.Y. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2007) [Pubmed]
  35. Tripartite control of growth hormone secretion in women during controlled estradiol repletion. Veldhuis, J.D., Cosma, M., Erickson, D., Paulo, R., Mielke, K., Farhy, L.S., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  36. Estimation of the size and shape of GH secretory bursts in healthy women using a physiological estradiol clamp and variable-waveform deconvolution model. Veldhuis, J.D., Keenan, D.M., Bowers, C.Y. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2007) [Pubmed]
  37. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. Veldhuis, J.D., Roemmich, J.N., Richmond, E.J., Bowers, C.Y. Endocr. Rev. (2006) [Pubmed]
  38. Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone. Veldhuis, J.D., Iranmanesh, A., Mielke, K., Miles, J.M., Carpenter, P.C., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  39. Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women. Veldhuis, J.D., Keenan, D.M., Iranmanesh, A., Mielke, K., Miles, J.M., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  40. Short-term aromatase-enzyme blockade unmasks impaired feedback adaptations in luteinizing hormone and testosterone secretion in older men. Veldhuis, J.D., Iranmanesh, A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  41. Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men. Veldhuis, J.D., Iranmanesh, A., Mulligan, T. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  42. Experimentally induced androgen depletion accentuates ethnicity-related contrasts in luteinizing hormone secretion in asian and caucasian men. Veldhuis, J.D., Bae, A., Swerdloff, R.S., Iranmanesh, A., Wang, C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  43. Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men. Veldhuis, J.D., Veldhuis, N.J., Keenan, D.M., Iranmanesh, A. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  44. Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations. Veldhuis, J.D., Anderson, S.M., Iranmanesh, A., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  45. Endocrine control of body composition in infancy, childhood, and puberty. Veldhuis, J.D., Roemmich, J.N., Richmond, E.J., Rogol, A.D., Lovejoy, J.C., Sheffield-Moore, M., Mauras, N., Bowers, C.Y. Endocr. Rev. (2005) [Pubmed]
  46. Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations. Veldhuis, J.D., Frystyk, J., Iranmanesh, A., Ørskov, H. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  47. Gender modulates sequential suppression and recovery of pulsatile growth hormone secretion by physiological feedback signals in young adults. Veldhuis, J.D., Farhy, L., Weltman, A.L., Kuipers, J., Weltman, J., Wideman, L. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  48. Joint mechanisms of impaired growth-hormone pulse renewal in aging men. Veldhuis, J.D., Iranmanesh, A., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  49. Mechanisms of ensemble failure of the male gonadal axis in aging. Veldhuis, J.D., Keenan, D.M., Iranmanesh, A. J. Endocrinol. Invest. (2005) [Pubmed]
  50. Distinctive inhibitory mechanisms of age and relative visceral adiposity on growth hormone secretion in pre- and postmenopausal women studied under a hypogonadal clamp. Veldhuis, J.D., Erickson, D., Mielke, K., Farhy, L.S., Keenan, D.M., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  51. Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy. Veldhuis, J.D., Keenan, D.M., Mielke, K., Miles, J.M., Bowers, C.Y. Eur. J. Endocrinol. (2005) [Pubmed]
  52. Administration of recombinant human GHRH-1,44-amide for 3 months reduces abdominal visceral fat mass and increases physical performance measures in postmenopausal women. Veldhuis, J.D., Patrie, J.M., Frick, K., Weltman, J.Y., Weltman, A.L. Eur. J. Endocrinol. (2005) [Pubmed]
  53. Sex-steroid control of the aging somatotropic axis. Veldhuis, J.D., Erickson, D., Iranmanesh, A., Miles, J.M., Bowers, C.Y. Endocrinol. Metab. Clin. North Am. (2005) [Pubmed]
  54. Aging-related adaptations in the corticotropic axis: modulation by gender. Veldhuis, J.D., Keenan, D.M., Roelfsema, F., Iranmanesh, A. Endocrinol. Metab. Clin. North Am. (2005) [Pubmed]
  55. Estradiol supplementation in postmenopausal women doubles rebound-like release of growth hormone (GH) triggered by sequential infusion and withdrawal of somatostatin: evidence that estrogen facilitates endogenous GH-releasing hormone drive. Veldhuis, J.D., Anderson, S.M., Patrie, J.T., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  56. Contrasting negative-feedback control of endogenously driven and exercise-stimulated pulsatile growth hormone secretion in women and men. Veldhuis, J.D., Patrie, J., Wideman, L., Patterson, M., Weltman, J.Y., Weltman, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  57. Short-term testosterone supplementation relieves growth hormone autonegative feedback in men. Veldhuis, J.D., Evans, W.S., Iranmanesh, A., Weltman, A.L., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  58. Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women. Veldhuis, J.D., Anderson, S.M., Kok, P., Iranmanesh, A., Frystyk, J., Ørskov, H., Keenan, D.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  59. Pulsatile intravenous infusion of recombinant human luteinizing hormone under acute gonadotropin-releasing hormone receptor blockade reconstitutes testosterone secretion in young men. Veldhuis, J.D., Iranmanesh, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  60. Age and secretagogue type jointly determine dynamic growth hormone responses to exogenous insulin-like growth factor-negative feedback in healthy men. Veldhuis, J.D., Weltman, J.Y., Weltman, A.L., Iranmanesh, A., Muller, E.E., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  61. Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men. Veldhuis, J.D., Iranmanesh, A., Keenan, D.M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  62. Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth hormone secretion in healthy middle-aged and older adults. Veldhuis, J.D., Patrie, J.T., Brill, K.T., Weltman, J.Y., Mueller, E.E., Bowers, C.Y., Weltman, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  63. Sustained growth hormone (GH) and insulin-like growth factor I responses to prolonged high-dose twice-daily GH-releasing hormone stimulation in middle-aged and older men. Veldhuis, J.D., Patrie, J.T., Frick, K., Weltman, J.Y., Weltman, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  64. Physiological control of pituitary hormone secretory-burst mass, frequency, and waveform: a statistical formulation and analysis. Keenan, D.M., Roelfsema, F., Biermasz, N., Veldhuis, J.D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  65. Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth hormone secretion: modulation by estrogen and aromatizable androgen. Veldhuis, J.D., Bowers, C.Y. J. Pediatr. Endocrinol. Metab. (2003) [Pubmed]
  66. Neuroendocrine facets of human puberty. Veldhuis, J.D. Neurobiol. Aging (2003) [Pubmed]
  67. A tripeptidyl ensemble perspective of interactive control of growth hormone secretion. Veldhuis, J.D. Horm. Res. (2003) [Pubmed]
  68. Estradiol supplementation enhances submaximal feed-forward drive of growth hormone (GH) secretion by recombinant human GH-releasing hormone-1,44-amide in a putatively somatostatin-withdrawn milieu. Veldhuis, J.D., Evans, W.S., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  69. Noninvasive in vivo investigative probes of adaptive mechanisms of neuroendocrine regulation: the paradigm of the hypothalamo-pituitary-gonadal axis in the aging male. Veldhuis, J.D., Pincus, S.M., Keenan, D.M. J. Endocrinol. Invest. (2003) [Pubmed]
  70. Sex-steroid modulation of growth hormone (GH) secretory control: three-peptide ensemble regulation under dual feedback restraint by GH and IGF-I. Veldhuis, J.D., Bowers, C.Y. Endocrine (2003) [Pubmed]
  71. Human GH pulsatility: an ensemble property regulated by age and gender. Veldhuis, J.D., Bowers, C.Y. J. Endocrinol. Invest. (2003) [Pubmed]
  72. Impact of experimental blockade of peripheral growth hormone (GH) receptors on the kinetics of endogenous and exogenous GH removal in healthy women and men. Veldhuis, J.D., Bidlingmaier, M., Anderson, S.M., Evans, W.S., Wu, Z., Strasburger, C.J. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
 
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