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V.L. Nienaber

Department of Structural Biology

Abbott Laboratories

Abbott Park

Illinois 60064

USA

[email]@abbott.com

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Affiliation

Department of Structural Biology, Abbott Laboratories, Abbott Park, Illinois 60064, USA. 2000

References

Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite. Nienaber, V., Wang, J., Davidson, D., Henkin, J. J. Biol. Chem. (2000) [Pubmed]
Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite. Nienaber, V.L., Davidson, D., Edalji, R., Giranda, V.L., Klinghofer, V., Henkin, J., Magdalinos, P., Mantei, R., Merrick, S., Severin, J.M., Smith, R.A., Stewart, K., Walter, K., Wang, J., Wendt, M., Weitzberg, M., Zhao, X., Rockway, T. Structure (2000) [Pubmed]
Discovering novel ligands for macromolecules using X-ray crystallographic screening. Nienaber, V.L., Richardson, P.L., Klighofer, V., Bouska, J.J., Giranda, V.L., Greer, J. Nat. Biotechnol. (2000) [Pubmed]