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Xi-Lin Chen

Discovery Research

AtheroGenics

Inc., 8995 Westside Parkway

Alpharetta

USA

[email]@atherogenics.com

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Affiliation

Discovery Research, AtheroGenics, Inc., 8995 Westside Parkway, Alpharetta, USA. 2003 - 2009

References

Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells. Chen, X.L., Dodd, G., Kunsch, C. Inflamm. Res. (2009) [Pubmed]
Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Chen, X.L., Dodd, G., Thomas, S., Zhang, X., Wasserman, M.A., Rovin, B.H., Kunsch, C. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase. Chen, X.L., Zhang, Q., Zhao, R., Medford, R.M. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Chen, X.L., Kunsch, C. Curr. Pharm. Des. (2004) [Pubmed]
Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow. Chen, X.L., Grey, J.Y., Thomas, S., Qiu, F.H., Medford, R.M., Wasserman, M.A., Kunsch, C. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism. Chen, X.L., Varner, S.E., Rao, A.S., Grey, J.Y., Thomas, S., Cook, C.K., Wasserman, M.A., Medford, R.M., Jaiswal, A.K., Kunsch, C. J. Biol. Chem. (2003) [Pubmed]
Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells. Chen, X.L., Zhang, Q., Zhao, R., Ding, X., Tummala, P.E., Medford, R.M. J. Pharmacol. Exp. Ther. (2003) [Pubmed]