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Zhengyin Yan

Division of Drug Discovery

Johnson & Johnson Pharmaceutical Research & Development

LLC, Spring House

Pennsylvania 19477

USA

[email]@prdus.jnj.com

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Affiliation

Division of Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, Pennsylvania 19477, USA. 2003 - 2008

References

Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition. Yan, Z., Caldwell, G.W., Maher, N. Anal. Chem. (2008) [Pubmed]
Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix. Yan, Z., Maher, N., Torres, R., Cotto, C., Hastings, B., Dasgupta, M., Hyman, R., Huebert, N., Caldwell, G.W. Rapid Commun. Mass Spectrom. (2008) [Pubmed]
Use of a trapping agent for simultaneous capturing and high-throughput screening of both "soft" and "hard" reactive metabolites. Yan, Z., Maher, N., Torres, R., Huebert, N. Anal. Chem. (2007) [Pubmed]
Metabolism and bioactivation of 3-methylindole by human liver microsomes. Yan, Z., Easterwood, L.M., Maher, N., Torres, R., Huebert, N., Yost, G.S. Chem. Res. Toxicol. (2007) [Pubmed]
N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-C]pyrazol-3-yl)-(3-fluoro-phenyl)-amine by human UDP-glucuronosyltransferases. Yan, Z., Caldwell, G.W., Gauthier, D., Leo, G.C., Mei, J., Ho, C.Y., Jones, W.J., Masucci, J.A., Tuman, R.W., Galemmo, R.A., Johnson, D.L. Drug Metab. Dispos. (2006) [Pubmed]
Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides. Yan, Z., Li, J., Huebert, N., Caldwell, G.W., Du, Y., Zhong, H. Drug Metab. Dispos. (2005) [Pubmed]
Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes. Yan, Z., Zhong, H.M., Maher, N., Torres, R., Leo, G.C., Caldwell, G.W., Huebert, N. Drug Metab. Dispos. (2005) [Pubmed]
Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry. Yan, Z., Maher, N., Torres, R., Caldwell, G.W., Huebert, N. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
A high-throughput monoamine oxidase inhibition assay using liquid chromatography with tandem mass spectrometry. Yan, Z., Caldwell, G.W., Zhao, B., Reitz, A.B. Rapid Commun. Mass Spectrom. (2004) [Pubmed]
Stable-isotope trapping and high-throughput screenings of reactive metabolites using the isotope MS signature. Yan, Z., Caldwell, G.W. Anal. Chem. (2004) [Pubmed]
Cone voltage induced in-source dissociation of glucuronides in electrospray and implications in biological analyses. Yan, Z., Caldwell, G.W., Jones, W.J., Masucci, J.A. Rapid Commun. Mass Spectrom. (2003) [Pubmed]