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Bindhu V. Karanam

Drug Metabolism and Pharmacokinetics

Merck Research Laboratories


NJ 07065



Name/email consistency: high



  • Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ 07065, USA. 2007 - 2010
  • RY 80L-109, Merck Research Laboratories, P.O. Box 2000, Rahway, USA. 2004


  1. Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans. Karanam, B., Addy, C., Bateman, T., Reddy, V.B., Li, S., Dean, D., Li, H., Jones, A., Schenk, D., Zhang, A.S., Braun, M., Freeman, A., Flach, S., Stoch, A., Chodakewitz, J., Wagner, J.A., Kumar, S. Xenobiotica (2010) [Pubmed]
  2. Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humans. Karanam, B., Madeira, M., Bradley, S., Wenning, L., Desai, R., Soli, E., Schenk, D., Jones, A., Dean, B., Doss, G., Garrett, G., Crumley, T., Nirula, A., Lai, E. Drug Metab. Dispos. (2007) [Pubmed]
  3. Effect of enalapril on the in vitro and in vivo peptidyl cleavage of a potent VLA-4 antagonist. Karanam, B.V., Jayraj, A., Rabe, M., Wang, Z., Keohane, C., Strauss, J., Vincent, S. Xenobiotica (2007) [Pubmed]
  4. Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonist. Karanam, B.V., Welch, C.J., Reddy, V.G., Chilenski, J., Biba, M., Vincent, S. Drug Metab. Dispos. (2004) [Pubmed]
  5. In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases. Karanam, B.V., Hop, C.E., Liu, D.Q., Wallace, M., Dean, D., Satoh, H., Komuro, M., Awano, K., Vincent, S.H. Drug Metab. Dispos. (2004) [Pubmed]
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