Dale L. Boger
Department of Chemistry and the Skaggs Institute for Chemical Biology
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla
USA
Name/email consistency: high
- Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. Boger, D.L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R.A., Cheng, H., Hwang, I., Hedrick, M.P., Leung, D., Acevedo, O., Guimarães, C.R., Jorgensen, W.L., Cravatt, B.F. J. Med. Chem. (2005)
- Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions. Boger, D.L. Bioorg. Med. Chem. (2003)
- Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions. Boger, D.L., Desharnais, J., Capps, K. Angew. Chem. Int. Ed. Engl. (2003)
- Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa. Boger, D.L., Hughes, T.V., Hedrick, M.P. J. Org. Chem. (2001)
- Cytokine receptor dimerization and activation: prospects for small molecule agonists. Boger, D.L., Goldberg, J. Bioorg. Med. Chem. (2001)
- alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. Boger, D.L., Miyauchi, H., Hedrick, M.P. Bioorg. Med. Chem. Lett. (2001)
- Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065. Boger, D.L., Stauffer, F., Hedrick, M.P. Bioorg. Med. Chem. Lett. (2001)
- Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins. Boger, D.L., Brunette, S.R., Garbaccio, R.M. J. Org. Chem. (2001)
- Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules. Boger, D.L., Tse, W.C. Bioorg. Med. Chem. (2001)
- Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain. Boger, D.L., Schmitt, H.W., Fink, B.E., Hedrick, M.P. J. Org. Chem. (2001)
- Vancomycin, teicoplanin, and ramoplanin: synthetic and mechanistic studies. Boger, D.L. Med. Res. Rev (2001)
- Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity. Boger, D.L., Searcey, M., Tse, W.C., Jin, Q. Bioorg. Med. Chem. Lett. (2000)
- Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Boger, D.L., Sato, H., Lerner, A.E., Hedrick, M.P., Fecik, R.A., Miyauchi, H., Wilkie, G.D., Austin, B.J., Patricelli, M.P., Cravatt, B.F. Proc. Natl. Acad. Sci. U.S.A. (2000)
- A new class of highly cytotoxic diketopiperazines. Boger, D.L., Fink, B.E., Hedrick, M.P. Bioorg. Med. Chem. Lett. (2000)
- Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase. Boger, D.L., Labroli, M.A., Marsilje, T.H., Jin, Q., Hedrick, M.P., Baker, S.J., Shim, J.H., Benkovic, S.J. Bioorg. Med. Chem. (2000)
- Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. Boger, D.L., Marsilje, T.H., Castro, R.A., Hedrick, M.P., Jin, Q., Baker, S.J., Shim, J.H., Benkovic, S.J. Bioorg. Med. Chem. Lett. (2000)
- Synthesis and evaluation of aza HUN-7293. Boger, D.L., Chen, Y., Foster, C.A. Bioorg. Med. Chem. Lett. (2000)
- Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis. Boger, D.L., Lee, J.K. J. Org. Chem. (2000)
- Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents. Boger, D.L., Dechantsreiter, M.A., Ishii, T., Fink, B.E., Hedrick, M.P. Bioorg. Med. Chem. (2000)
- Asymmetric synthesis of orthogonally protected L-threo-beta-hydroxyasparagine. Boger, D.L., Lee, R.J., Bounaud, P.Y., Meier, P. J. Org. Chem. (2000)
- Fatty acid amide hydrolase substrate specificity. Boger, D.L., Fecik, R.A., Patterson, J.E., Miyauchi, H., Patricelli, M.P., Cravatt, B.F. Bioorg. Med. Chem. Lett. (2000)
- Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine. Boger, D.L., Wolkenberg, S.E. J. Org. Chem. (2000)
- Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Boger, D.L., Henriksen, S.J., Cravatt, B.F. Curr. Pharm. Des. (1998)
- Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide. Boger, D.L., Patterson, J.E., Jin, Q. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Boger, D.L., Patterson, J.E., Guan, X., Cravatt, B.F., Lerner, R.A., Gilula, N.B. Proc. Natl. Acad. Sci. U.S.A. (1998)
