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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Gerhard Bringmann

Institute of Organic Chemistry

University of Würzburg

Am Hubland

D-97074 Würzburg



Name/email consistency: high



  • Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. 1999 - 2010


  1. Total synthesis of the N,C-coupled naphthylisoquinoline alkaloids ancistrocladinium A and B and related analogues. Bringmann, G., Gulder, T., Hertlein, B., Hemberger, Y., Meyer, F. J. Am. Chem. Soc. (2010) [Pubmed]
  2. Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinone chrysophanol. Bringmann, G., Gulder, T.A., Hamm, A., Goodfellow, M., Fiedler, H.P. Chem. Commun. (Camb.) (2009) [Pubmed]
  3. Convergence in the biosynthesis of acetogenic natural products from plants, fungi, and bacteria. Bringmann, G., Irmer, A., Feineis, D., Gulder, T.A., Fiedler, H.P. Phytochemistry (2009) [Pubmed]
  4. The online assignment of the absolute configuration of natural products: HPLC-CD in combination with quantum chemical CD calculations. Bringmann, G., Gulder, T.A., Reichert, M., Gulder, T. Chirality (2008) [Pubmed]
  5. Joziknipholones A and B: the first dimeric phenylanthraquinones, from the roots of Bulbine frutescens. Bringmann, G., Mutanyatta-Comar, J., Maksimenka, K., Wanjohi, J.M., Heydenreich, M., Brun, R., Müller, W.E., Peter, M.G., Midiwo, J.O., Yenesew, A. Chemistry (2008) [Pubmed]
  6. Knipholone and related 4-phenylanthraquinones: structurally, pharmacologically, and biosynthetically remarkable natural products. Bringmann, G., Mutanyatta-Comar, J., Knauer, M., Abegaz, B.M. Nat. Prod. Rep (2008) [Pubmed]
  7. Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and Ancistrocladus abbreviatus (Ancistrocladaceae). Bringmann, G., Rüdenauer, S., Irmer, A., Bruhn, T., Brun, R., Heimberger, T., Stühmer, T., Bargou, R., Chatterjee, M. Phytochemistry (2008) [Pubmed]
  8. Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids. Bringmann, G., Brun, R., Kaiser, M., Neumann, S. Eur. J. Med. Chem (2008) [Pubmed]
  9. Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042. Bringmann, G., Haagen, Y., Gulder, T.A., Gulder, T., Heide, L. J. Org. Chem. (2007) [Pubmed]
  10. Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines. Bringmann, G., Gampe, C.M., Reichert, Y., Bruhn, T., Faber, J.H., Mikyna, M., Reichert, M., Leippe, M., Brun, R., Gelhaus, C. J. Med. Chem. (2007) [Pubmed]
  11. Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A. Bringmann, G., Gulder, T.A., Lang, G., Schmitt, S., Stöhr, R., Wiese, J., Nagel, K., Imhoff, J.F. Mar. Drugs (2007) [Pubmed]
  12. Polyketide folding in higher plants: biosynthesis of the phenylanthraquinone knipholone. Bringmann, G., Noll, T.F., Gulder, T., Dreyer, M., Grüne, M., Moskau, D. J. Org. Chem. (2007) [Pubmed]
  13. Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese ancistrocladus species. Bringmann, G., Kajahn, I., Reichert, M., Pedersen, S.E., Faber, J.H., Gulder, T., Brun, R., Christensen, S.B., Ponte-Sucre, A., Moll, H., Heubl, G., Mudogo, V. J. Org. Chem. (2006) [Pubmed]
  14. Synthesis of radiolabelled 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo), a neurotoxic chloral-derived mammalian alkaloid, and its biodistribution in rats. Bringmann, G., Feineis, D., Brückner, R., God, R., Grote, C., Wesemann, W. Eur. J. Pharm. Sci (2006) [Pubmed]
  15. Different polyketide folding modes converge to an identical molecular architecture. Bringmann, G., Noll, T.F., Gulder, T.A., Grüne, M., Dreyer, M., Wilde, C., Pankewitz, F., Hilker, M., Payne, G.D., Jones, A.L., Goodfellow, M., Fiedler, H.P. Nat. Chem. Biol. (2006) [Pubmed]
  16. Toxicity and metabolism of the chloral-derived mammalian alkaloid 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) in PC12 cells. Bringmann, G., Feineis, D., Münchbach, M., God, R., Peters, K., Peters, E.M., Mössner, R., Lesch, K.P. Z. Naturforsch., C, J. Biosci. (2006) [Pubmed]
  17. Axially chiral directly beta,beta-linked bisporphyrins: synthesis and stereostructure. Bringmann, G., Rüdenauer, S., Götz, D.C., Gulder, T.A., Reichert, M. Org. Lett. (2006) [Pubmed]
  18. Analysis of the glucosinolate pattern of Arabidopsis thaliana seeds by capillary zone electrophoresis coupled to electrospray ionization-mass spectrometry. Bringmann, G., Kajahn, I., Neusüss, C., Pelzing, M., Laug, S., Unger, M., Holzgrabe, U. Electrophoresis (2005) [Pubmed]
  19. Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14. Bringmann, G., Lang, G., Maksimenka, K., Hamm, A., Gulder, T.A., Dieter, A., Bull, A.T., Stach, J.E., Kocher, N., Müller, W.E., Fiedler, H.P. Phytochemistry (2005) [Pubmed]
  20. ent-Dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the "new"plant species Ancistrocladus benomensis. Bringmann, G., Dreyer, M., Kopff, H., Rischer, H., Wohlfarth, M., Hadi, H.A., Brun, R., Meimberg, H., Heubl, G. J. Nat. Prod. (2005) [Pubmed]
  21. Atroposelective synthesis of axially chiral biaryl compounds. Bringmann, G., Price Mortimer, A.J., Keller, P.A., Gresser, M.J., Garner, J., Breuning, M. Angew. Chem. Int. Ed. Engl. (2005) [Pubmed]
  22. Petrosifungins A and B, novel cyclodepsipeptides from a sponge-derived strain of Penicillium brevicompactum. Bringmann, G., Lang, G., Steffens, S., Schaumann, K. J. Nat. Prod. (2004) [Pubmed]
  23. Stereochemistry of isoplagiochin C, a macrocyclic bisbibenzyl from liverworts. Bringmann, G., Mühlbacher, J., Reichert, M., Dreyer, M., Kolz, J., Speicher, A. J. Am. Chem. Soc. (2004) [Pubmed]
  24. Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species ancistrocladusbenomensis. Bringmann, G., Dreyer, M., Rischer, H., Wolf, K., Hadi, H.A., Brun, R., Meimberg, H., Heubl, G. J. Nat. Prod. (2004) [Pubmed]
  25. 3D QSAR investigations on antimalarial naphthylisoquinoline alkaloids by comparative molecular similarity indices analysis (CoMSIA), based on different alignment approaches. Bringmann, G., Rummey, C. J. Chem. Inf. Comput. Sci (2003) [Pubmed]
  26. Ancistrolikokine D, a 5,8'-coupled naphthylisoquinoline alkaloid, and related natural products from Ancistrocladus likoko. Bringmann, G., Saeb, W., Rückert, M., Mies, J., Michel, M., Mudogo, V., Brun, R. Phytochemistry (2003) [Pubmed]
  27. Habropetaline A, an antimalarial naphthylisoquinoline alkaloid from Triphyophyllum peltatum. Bringmann, G., Messer, K., Schwöbel, B., Brun, R., Aké Assi, L. Phytochemistry (2003) [Pubmed]
  28. Synthesis of enantiopure axially chiral C3-symmetric tripodal ligands and their application as catalysts in the asymmetric addition of dialkylzinc to aldehydes. Bringmann, G., Pfeifer, R.M., Rummey, C., Hartner, K., Breuning, M. J. Org. Chem. (2003) [Pubmed]
  29. Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis. Bringmann, G., Dreyer, M., Faber, J.H., Dalsgaard, P.W., Staerk, D., Jaroszewski, J.W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M., Maksimenka, K., Christensen, S.B. J. Nat. Prod. (2003) [Pubmed]
  30. Endogenous alkaloids in man. XXXVIII. "Chiral" and "achiral" determination of the neurotoxin TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline) from blood and urine samples by high-performance liquid chromatography--electrospray ionization tandem mass spectrometry. Bringmann, G., Münchbach, M., Feineis, D., Messer, K., Diem, S., Herderich, M., Clement, H.W., Stichel-Gunkel, C., Kuhn, W. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2002) [Pubmed]
  31. Dioncophylline E from Dioncophyllum thollonii, the first 7,3'-coupled dioncophyllaceous naphthylisoquinoline alkaloid. Bringmann, G., Messer, K., Wolf, K., Mühlbacher, J., Grüne, M., Brun, R., Louis, A.M. Phytochemistry (2002) [Pubmed]
  32. Atropo-enantioselective total synthesis of knipholone and related antiplasmodial phenylanthraquinones. Bringmann, G., Menche, D., Kraus, J., Mühlbacher, J., Peters, K., Peters, E.M., Brun, R., Bezabih, M., Abegaz, B.M. J. Org. Chem. (2002) [Pubmed]
  33. Extract screening by HPLC coupled to MS-MS, NMR, and CD: a dimeric and three monomeric naphthylisoquinoline alkaloids from Ancistrocladus griffithii. Bringmann, G., Wohlfarth, M., Rischer, H., Schlauer, J., Brun, R. Phytochemistry (2002) [Pubmed]
  34. On the verge of axial chirality: atroposelective synthesis of the AB-biaryl fragment of vancomycin. Bringmann, G., Menche, D., Mühlbacher, J., Reichert, M., Saito, N., Pfeiffer, S.S., Lipshutz, B.H. Org. Lett. (2002) [Pubmed]
  35. Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis. Bringmann, G., Messer, K., Brun, R., Mudogo, V. J. Nat. Prod. (2002) [Pubmed]
  36. The absolute configuration of (+)-isoshinanolone and in situ LC-CD analysis of its stereoisomers from crude extracts. Bringmann, G., Messer, K., Saeb, W., Peters, E.M., Peters, K. Phytochemistry (2001) [Pubmed]
  37. Studies on single-strand scissions to cell-free plasmid DNA by the dopaminergic neurotoxin 'TaClo' (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline). Bringmann, G., Münchbach, M., Feineis, D., Faulhaber, K., Ihmels, H. Neurosci. Lett. (2001) [Pubmed]
  38. A photometric screening method for dimeric naphthylisoquinoline alkaloids and complete on-line structural elucidation of a dimer in crude plant extracts, by the LC-MS/LC-NMR/LC-CD triad. Bringmann, G., Wohlfarth, M., Rischer, H., Heubes, M., Saeb, W., Diem, S., Herderich, M., Schlauer, J. Anal. Chem. (2001) [Pubmed]
  39. Synthesis of a chiral aryl-ferrocenyl ligand, by intramolecular coupling to a biaryl-related lactone. Bringmann, G., Hinrichs, J., Peters, K., Peters, E.M. J. Org. Chem. (2001) [Pubmed]
  40. Murrastifoline-F: first total synthesis, atropo-enantiomer resolution, and stereoanalysis of an axially chiral N,C-coupled biaryl alkaloid. Bringmann, G., Tasler, S., Endress, H., Kraus, J., Messer, K., Wohlfarth, M., Lobin, W. J. Am. Chem. Soc. (2001) [Pubmed]
  41. Stress-related polyketide metabolism of Dioncophyllaceae and Ancistrocladaceae. Bringmann, G., Feineis, D. J. Exp. Bot. (2001) [Pubmed]
  42. Biaryls in nature: a multi-facetted class of stereochemically, biosynthetically, and pharmacologically intriguing secondary metabolites. Bringmann, G., Günther, C., Ochse, M., Schupp, O., Tasler, S. Fortschr. Chem. Org. Naturst (2001) [Pubmed]
  43. Droserone from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and its biosynthetic origin. Bringmann, G., Rischer, H., Wohlfarth, M., Schlauer, J., Assi, L.A. Phytochemistry (2000) [Pubmed]
  44. Tropane alkaloids from Erythroxylum zeylanicum O.E. Schulz (Erythroxylaceae). Bringmann, G., Günther, C., Mühlbacher, J., Lalith, M.D., Gunathilake, P., Wickramasinghe, A. Phytochemistry (2000) [Pubmed]
  45. First atropo-divergent total synthesis of the antimalarial korupensamines A and B by the "lactone method". Bringmann, G., Ochse, M., Götz, R. J. Org. Chem. (2000) [Pubmed]
  46. Nondynamic kinetic resolution of configurationally stable biaryl lactones by reduction with oxazaborolidine-activated borane: AM1 studies and experimental verification. Bringmann, G., Hinrichs, J., Kraus, J., Wuzik, A., Schulz, T. J. Org. Chem. (2000) [Pubmed]
  47. 6-Hydroxyluteolin-7-O-(1''-alpha-rhamnoside) from Vriesea sanguinolenta Cogn. and Marchal (Bromeliaceae). Bringmann, G., Ochse, M., Zotz, G., Peters, K., Peters, E.M., Brun, R., Schlauer, J. Phytochemistry (2000) [Pubmed]
  48. 8-O-methyldioncophyllinol B and revised structures of other 7,6'-coupled naphthylisoquinoline alkaloids from Triphyophyllum peltatum (Dioncophyllaceae). Bringmann, G., Günther, C., Saeb, W., Mies, J., Brun, R., Assi, L.A. Phytochemistry (2000) [Pubmed]
  49. Bromal-derived tetrahydro-beta-carbolines as neurotoxic agents: chemistry, impairment of the dopamine metabolism, and inhibitory effects on mitochondrial respiration. Bringmann, G., Feineis, D., Brückner, R., Blank, M., Peters, K., Peters, E.M., Reichmann, H., Janetzky, B., Grote, C., Clement, H.W., Wesemann, W. Bioorg. Med. Chem. (2000) [Pubmed]
  50. Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis. Bringmann, G., Hamm, A., Günther, C., Michel, M., Brun, R., Mudogo, V. J. Nat. Prod. (2000) [Pubmed]
  51. Observation of exchangeable protons by high-performance liquid chromatography-nuclear magnetic resonance spectroscopy and high-performance liquid chromatography-electrospray ionization mass spectrometry: a useful tool for the hyphenated analysis of natural products. Bringmann, G., Wohlfarth, M., Heubes, M. J. Chromatogr. A (2000) [Pubmed]
  52. Identification of the dopaminergic neurotoxin 1-trichloromethyl-1,2, 3,4-tetrahydro-beta-carboline in human blood after intake of the hypnotic chloral hydrate. Bringmann, G., God, R., Fähr, S., Feineis, D., Fornadi, K., Fornadi, F. Anal. Biochem. (1999) [Pubmed]
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