C. Arnold Spek
Center for Experimental and Molecular Medicine
Academic Medical Center
Room H2-257
Meibergdreef 9
E-mail:
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- Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice. Borensztajn, K., Duitman, J., Brüggemann, L.W., Spek, C.A. Eur. Respir. J. (2012)
- Factor V Leiden and the etiology of inflammatory bowel disease. Spek, C.A., ten Kate, F.J., te Velde, A.A. Thromb. Haemost. (2007)
- Tissue factor: from 'just one of the coagulation factors' to a major player in physiology. Spek, C.A. Blood Coagul. Fibrinolysis (2004)
- Treatment with an anti-CD14 monoclonal antibody delays and inhibits lipopolysaccharide-induced gene expression in humans in vivo. Spek, C.A., Verbon, A., Aberson, H., Pribble, J.P., McElgunn, C.J., Turner, T., Axtelle, T., Schouten, J., Van Der Poll, T., Reitsma, P.H. J. Clin. Immunol. (2003)
- Genetic risk factors for venous thrombosis. Spek, C.A., Reitsma, P.H. Mol. Genet. Metab. (2000)
- Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity. Spek, C.A., Bertina, R.M., Reitsma, P.H. Biochem. J. (1999)
- Type I protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter. Spek, C.A., Lannoy, V.J., Lemaigre, F.P., Rousseau, G.G., Bertina, R.M., Reitsma, P.H. J. Biol. Chem. (1998)