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Abdul E. Mutlib

Drug Metabolism and Pharmacokinetics Section

DuPont Pharmaceuticals Company

Stine-Haskell Research Center

Newark

USA

[email]@dupontpharma.com

Name/email consistency: high

 
 
 
 
 
 
 

Affiliation

  • Drug Metabolism and Pharmacokinetics Section, DuPont Pharmaceuticals Company, Stine-Haskell Research Center, Newark, USA. 1999 - 2002

References

  1. Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR. Mutlib, A.E., Shockcor, J., Chen, S.Y., Espina, R.J., Pinto, D.J., Orwat, M.J., Prakash, S.R., Gan, L.S. Chem. Res. Toxicol. (2002) [Pubmed]
  2. P450-mediated metabolism of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)- [1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole- 5-carboxamide (DPC 423) and its analogues to aldoximes. Characterization of glutathione conjugates of postulated intermediates derived from aldoximes. Mutlib, A.E., Chen, S.Y., Espina, R.J., Shockcor, J., Prakash, S.R., Gan, L.S. Chem. Res. Toxicol. (2002) [Pubmed]
  3. Formation of unusual glutamate conjugates of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) and its analogs: the role of gamma-glutamyltranspeptidase in the biotransformation of benzylamines. Mutlib, A., Shockcor, J., Chen, S.Y., Espina, R., Lin, J., Graciani, N., Prakash, S., Gan, L.S. Drug Metab. Dispos. (2001) [Pubmed]
  4. Disposition of glutathione conjugates in rats by a novel glutamic acid pathway: characterization of unique peptide conjugates by liquid chromatography/mass spectrometry and liquid chromatography/NMR. Mutlib, A.E., Shockcor, J., Espina, R., Graciani, N., Du, A., Gan, L.S. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  5. Characterization of novel glutathione adducts of a non-nucleoside reverse transcriptase inhibitor, (S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3, 4-dihydro-2(1H)-quinazolinone (DPC 961), in rats. Possible formation of an oxirene metabolic intermediate from a disubstituted alkyne. Mutlib, A., Chen, H., Shockcor, J., Espina, R., Chen, S., Cao, K., Du, A., Nemeth, G., Prakash, S., Gan, L.S. Chem. Res. Toxicol. (2000) [Pubmed]
  6. Mass spectrometric and NMR characterization of metabolites of roxifiban, a potent and selective antagonist of the platelet glycoprotein IIb/IIIa receptor. Mutlib, A.E., Diamond, S., Shockcor, J., Way, R., Nemeth, G., Gan, L., Christ, D.D. Xenobiotica (2000) [Pubmed]
  7. Liquid chromatography/mass spectrometry and high-field nuclear magnetic resonance characterization of novel mixed diconjugates of the non-nucleoside human immunodeficiency virus-1 reverse transcriptase inhibitor, efavirenz. Mutlib, A.E., Chen, H., Nemeth, G., Gan, L.S., Christ, D.D. Drug Metab. Dispos. (1999) [Pubmed]
  8. Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz. Mutlib, A.E., Chen, H., Nemeth, G.A., Markwalder, J.A., Seitz, S.P., Gan, L.S., Christ, D.D. Drug Metab. Dispos. (1999) [Pubmed]
 
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