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Jae Jin Chae

Laboratory of Clinical Investigation

National Institutes of Arthritis and Musculoskeletal and Skin Diseases

Genetics and Genomics Branch

Bethesda

USA

[email]@exchange.nih.gov

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Affiliation

Laboratory of Clinical Investigation, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, Genetics and Genomics Branch, Bethesda, USA. 2003 - 2009

References

Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy. Chae, J.J., Aksentijevich, I., Kastner, D.L. Br. J. Haematol. (2009) [Pubmed]
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment. Chae, J.J., Wood, G., Richard, K., Jaffe, H., Colburn, N.T., Masters, S.L., Gumucio, D.L., Shoham, N.G., Kastner, D.L. Blood (2008) [Pubmed]
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Chae, J.J., Wood, G., Masters, S.L., Richard, K., Park, G., Smith, B.J., Kastner, D.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Chae, J.J., Komarow, H.D., Cheng, J., Wood, G., Raben, N., Liu, P.P., Kastner, D.L. Mol. Cell (2003) [Pubmed]