Dirk Beher
Department of Biochemistry & Molecular Biology
Merck Sharp & Dohme Research Laboratories
The Neuroscience Research Centre
Terlings Park
United Kingdom
Name/email consistency: high
- Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease. Beher, D., Graham, S.L. Expert. Opin. Investig. Drugs (2005)
- Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism. Beher, D., Clarke, E.E., Wrigley, J.D., Martin, A.C., Nadin, A., Churcher, I., Shearman, M.S. J. Biol. Chem. (2004)
- In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand. Beher, D., Fricker, M., Nadin, A., Clarke, E.E., Wrigley, J.D., Li, Y.M., Culvenor, J.G., Masters, C.L., Harrison, T., Shearman, M.S. Biochemistry (2003)
- Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity. Beher, D., Wrigley, J.D., Owens, A.P., Shearman, M.S. J. Neurochem. (2002)
- Gamma-secretase inhibition. Beher, D., Shearman, M.S. Biochem. Soc. Trans. (2002)
- Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. Beher, D., Wrigley, J.D., Nadin, A., Evin, G., Masters, C.L., Harrison, T., Castro, J.L., Shearman, M.S. J. Biol. Chem. (2001)